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Evidence Snapshot

Staphylococcus aureus

CHEMBL352 ORGANISM Staphylococcus aureus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T23:51:40Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL352
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Staphylococcus aureus as ChEMBL target CHEMBL352. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Staphylococcus aureus
ORGANISM · Staphylococcus aureus
As of 2026-09-13
ChEMBL target ID
CHEMBL352
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Staphylococcus aureus matters

As of 2026-09-13

Staphylococcus aureus is reviewed as Staphylococcus aureus; the current evidence base includes 39 approved drugs, 83309 compounds, and 32915 assays, with lead potency reaching pChEMBL 9.4.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 39 approved drugs, 83309 compounds, and 32915 assays for this target. The dominant activity type is IC50. CHEMBL3814424 is the current potency anchor at pChEMBL 9.4.

Use CHEMBL3814424 as the tractability anchor when discussing potency (pChEMBL 9.4).

Activity source · ChEMBL 36 via Core Engine
39 approved pChEMBL 9.4
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Staphylococcus aureus matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

83309
Total Compounds
32915
Total Assays
39
Approved Drugs
IC50: 3170.0, KI: 2.0, EC50: 584.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL3814424
 9.4 IC50 —
No preferred name
CHEMBL262777
 9.4 IC50 Approved
No preferred name
CHEMBL4161555
 8.7 IC50 —
No preferred name
CHEMBL186155
 8.7 IC50 —
No preferred name
CHEMBL4162120
 8.6 IC50 —

Approved Drugs

Structure Compound First Approval
DAPTOMYCIN
CHEMBL387675
 2003
MEROPENEM
CHEMBL127
 1996
LEVOFLOXACIN
CHEMBL5315124
 1996
DICLOFENAC
CHEMBL139
 1988
NAFTIFINE HYDROCHLORIDE
CHEMBL1200493
 1988
CIPROFLOXACIN
CHEMBL8
 1987
METHICILLIN
CHEMBL575
 1982
CEFOTAXIME
CHEMBL1730
 1981
MITOMYCIN
CHEMBL105
 1981
MECLOFENAMIC ACID
CHEMBL509
 1980
AMOXICILLIN
CHEMBL1082
 1974
KANAMYCIN
CHEMBL1384
 1973
RIFAMPIN
CHEMBL374478
 1971
CEPHALEXIN ANHYDROUS
CHEMBL1727
 1971
MINOCYCLINE
CHEMBL1434
 1971
DOXYCYCLINE
CHEMBL1200699
 1967
AMPICILLIN
CHEMBL174
 1965
VANCOMYCIN
CHEMBL262777
 1964
ERYTHROMYCIN
CHEMBL532
 1964
NOVOBIOCIN
CHEMBL36506
 1964
CHLORAMPHENICOL
CHEMBL130
 1950
BENZBROMARONE
CHEMBL388590
 —
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T23:51:40Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL352