Compound Detail
CHEMBL387675
DAPTOMYCIN 💊 Approved Drug
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💊 Approved Drug
CCCCCCCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@@H]([C@H](C)CC(=O)O)C(=O)N[C@@H](CC(=O)c2ccccc2N)C(=O)O[C@@H]1C
Basic Information
| ChEMBL ID | CHEMBL387675 |
| Name | DAPTOMYCIN |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | DOAKLVKFURWEDJ-RWDRXURGSA-N |
| Therapeutic | ✓ Yes |
3
Targets
7
Activities
2
Assay Types
0
PK Parameters
20
Publications
12
Known Names
20
Indications
1
Mechanisms
Molecular Properties
1620.7
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2003 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Cell membrane inhibitor | INHIBITOR | Cell membrane | ✓ | ✓ |
Indications
Bacteremia Bacterial Infections Endocarditis Endocarditis Endocarditis, Bacterial Gram-Positive Bacterial Infections Infections Skin Diseases, Bacterial Soft Tissue Infections Cross Infection Diabetic Foot Osteomyelitis Pneumonia, Bacterial Renal Insufficiency Skin Diseases Staphylococcal Infections Hematologic Neoplasms Meningitis, Pneumococcal Meningitis Renal Insufficiency, Chronic
ATC Classification
J01XX09
daptomycin
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIBACTERIALS FOR SYSTEMIC USE
Activity Summary
EC50 6 meas. best 6.17
IC50 1 meas. best 4.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Staphylococcus aureus CHEMBL352 | EC50 | 6.17 | 5.6625 | 680.0 | 4 |
| Enterococcus faecium CHEMBL357 | EC50 | 5.04 | 4.76 | 9200.0 | 2 |
| ATP-binding cassette sub-family C member 2 CHEMBL5748 | IC50 | 4.54 | 4.54 | 29100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine