Assay Detail
ADMET
CHEMBL4028922
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay
598
Total Activities
598
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
ATP-binding cassette sub-family C member 2 (CHEMBL5748) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 590 | 4.44 | 5.42 |
| Inhibition | 8 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL456 | ETHACRYNIC ACID | 4.0 | 1 | 5.42 |
| CHEMBL1292 | CLOFAZIMINE | 4.0 | 1 | 4.98 |
| CHEMBL1908360 | EVEROLIMUS | 4.0 | 1 | 4.95 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 4.84 |
| CHEMBL1617 | RIFAXIMIN | 4.0 | 1 | 4.81 |
| CHEMBL1660 | RIFAPENTINE | 4.0 | 1 | 4.79 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 4.75 |
| CHEMBL387675 | DAPTOMYCIN | 4.0 | 1 | 4.54 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 4.43 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | 4.0 | 1 | 4.39 |
| CHEMBL388590 | BENZBROMARONE | 4.0 | 1 | 4.38 |
| CHEMBL428496 | WORTMANNIN | — | 1 | 4.34 |
| CHEMBL444633 | RIFABUTIN | 4.0 | 1 | 4.30 |
| CHEMBL374478 | RIFAMPIN | 4.0 | 1 | 4.28 |
| CHEMBL5314359 | — | — | 1 | 4.25 |
| CHEMBL813 | EPROSARTAN | 4.0 | 1 | 4.24 |
| CHEMBL603 | ZAFIRLUKAST | 4.0 | 1 | 4.23 |
| CHEMBL77305 | RUBITECAN | 3.0 | 1 | 4.22 |
| CHEMBL1096885 | VALRUBICIN | 4.0 | 1 | 4.19 |
| CHEMBL4063475 | — | — | 1 | 4.19 |
| CHEMBL772 | RESERPINE | 4.0 | 1 | 4.17 |
| CHEMBL1272 | REPAGLINIDE | 4.0 | 1 | 4.14 |
| CHEMBL1200775 | LEUPROLIDE ACETATE | 4.0 | 1 | 4.10 |
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | 4.07 |
| CHEMBL1541 | CEFIXIME | 4.0 | 1 | 4.05 |
| CHEMBL1200963 | BIMATOPROST | 4.0 | 1 | - |
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | - |
| CHEMBL4064157 | — | — | 1 | - |
| CHEMBL1370 | BUDESONIDE | 4.0 | 1 | - |
| CHEMBL1200792 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL456 | ETHACRYNIC ACID | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL1292 | CLOFAZIMINE | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL1908360 | EVEROLIMUS | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL1617 | RIFAXIMIN | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL1660 | RIFAPENTINE | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL387675 | DAPTOMYCIN | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL265502 | SURAMIN | IC50 | = | 36800.0 | nM | 4.43 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | IC50 | = | 40300.0 | nM | 4.39 |
| CHEMBL388590 | BENZBROMARONE | IC50 | = | 41600.0 | nM | 4.38 |
| CHEMBL428496 | WORTMANNIN | IC50 | = | 46100.0 | nM | 4.34 |
| CHEMBL444633 | RIFABUTIN | IC50 | = | 49800.0 | nM | 4.30 |
| CHEMBL374478 | RIFAMPIN | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL5314359 | — | IC50 | = | 56200.0 | nM | 4.25 |
| CHEMBL813 | EPROSARTAN | IC50 | = | 57900.0 | nM | 4.24 |
| CHEMBL603 | ZAFIRLUKAST | IC50 | = | 58800.0 | nM | 4.23 |
| CHEMBL77305 | RUBITECAN | IC50 | = | 60500.0 | nM | 4.22 |
| CHEMBL4063475 | — | IC50 | = | 64200.0 | nM | 4.19 |
| CHEMBL1096885 | VALRUBICIN | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL772 | RESERPINE | IC50 | = | 68400.0 | nM | 4.17 |
| CHEMBL1272 | REPAGLINIDE | IC50 | = | 72300.0 | nM | 4.14 |
| CHEMBL1200775 | LEUPROLIDE ACETATE | IC50 | = | 80200.0 | nM | 4.10 |
| CHEMBL56337 | EPALRESTAT | IC50 | = | 84400.0 | nM | 4.07 |
| CHEMBL1541 | CEFIXIME | IC50 | = | 89400.0 | nM | 4.05 |
| CHEMBL802 | MINOXIDIL | IC50 | > | 133000.0 | nM | - |
| CHEMBL86 | METOCLOPRAMIDE | IC50 | > | 133000.0 | nM | - |
| CHEMBL127 | MEROPENEM | IC50 | > | 133000.0 | nM | - |
| CHEMBL975 | MESNA | IC50 | > | 133000.0 | nM | - |
| CHEMBL1431 | METFORMIN | IC50 | > | 133000.0 | nM | - |
| CHEMBL1515 | METHIMAZOLE | IC50 | > | 133000.0 | nM | - |
| CHEMBL34259 | METHOTREXATE | IC50 | > | 133000.0 | nM | - |
| CHEMBL1531134 | MELPERONE | IC50 | > | 133000.0 | nM | - |
| CHEMBL45 | MELATONIN | IC50 | > | 133000.0 | nM | - |
| CHEMBL137 | METRONIDAZOLE | IC50 | > | 133000.0 | nM | - |
| CHEMBL266510 | FLINDOKALNER | IC50 | > | 133000.0 | nM | - |
| CHEMBL13 | METOPROLOL | IC50 | > | 133000.0 | nM | - |
| CHEMBL21731 | MAPROTILINE | IC50 | > | 133000.0 | nM | - |
| CHEMBL1201161 | MAFENIDE ACETATE | IC50 | > | 133000.0 | nM | - |
| CHEMBL373742 | VASOPRESSIN | IC50 | > | 133000.0 | nM | - |
| CHEMBL654 | MIRTAZAPINE | IC50 | > | 133000.0 | nM | - |
| CHEMBL245019 | MIZORIBINE | IC50 | > | 133000.0 | nM | - |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | > | 133000.0 | nM | - |
| CHEMBL1329455 | MOLSIDOMINE | IC50 | > | 133000.0 | nM | - |
| CHEMBL1200735 | MOXIFLOXACIN HYDROCHLORIDE | IC50 | > | 133000.0 | nM | - |
| CHEMBL719 | MUPIROCIN | IC50 | > | 133000.0 | nM | - |
| CHEMBL521606 | NADOLOL | IC50 | > | 133000.0 | nM | - |
| CHEMBL1200343 | PERINDOPRIL ERBUMINE | IC50 | > | 133000.0 | nM | - |
| CHEMBL852 | MELPHALAN | IC50 | > | 133000.0 | nM | - |
| CHEMBL404108 | LUMIRACOXIB | IC50 | > | 133000.0 | nM | - |