Compound Detail
CHEMBL245019
MIZORIBINE 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL245019 |
| Name | MIZORIBINE |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | HZQDCMWJEBCWBR-UUOKFMHZSA-N |
| Active Moiety | CHEMBL1794685 |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
20
Publications
4
Known Names
3
Indications
2
Mechanisms
Molecular Properties
259.2
MW (Da)
-2.70
ALogP
8
HBA
5
HBD
151.1
PSA (Ų)
0.40
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor | INHIBITOR | Inosine-5'-monophosphate dehydrogenase (IMPDH) | ✓ | ✓ |
| GMP synthase [glutamine-hydrolyzing] inhibitor | INHIBITOR | GMP synthase [glutamine-hydrolyzing] | ✓ | ✓ |
Indications
Arthritis, Rheumatoid Lupus Nephritis Nephrotic Syndrome
Activity Summary
IC50 1 meas. best 4.87
Ki 1 meas. best 4.0
Target Activity Profile
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| SARS-CoV | IC50 | = | 13500.0 | nM | 4.87 | Antiviral activity against SARS-CoV Frankfurt1 in Vero E6 cells by plaque reduct... | 17336519 |
| Unchecked | Ki | = | 100000.0 | nM | 4.0 | Inhibition of GMP synthase (unknown origin) | 27607900 |
Literature References
Data from ChEMBL 36 via Core Engine