Assay Detail
Functional
CHEMBL887577
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV Frankfurt1 in Vero E6 cells by plaque reduction assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
SARS-CoV (CHEMBL4303836) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.53 | 4.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245019 | MIZORIBINE | 3.0 | 1 | 4.87 |
| CHEMBL243757 | — | — | 1 | 4.84 |
| CHEMBL397974 | — | — | 1 | 4.31 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 4.09 |
| CHEMBL388704 | — | — | 1 | - |
| CHEMBL244381 | — | — | 1 | - |
| CHEMBL388932 | — | — | 1 | - |
| CHEMBL244380 | — | — | 1 | - |
| CHEMBL244379 | — | — | 1 | - |
| CHEMBL244169 | — | — | 1 | - |
| CHEMBL388931 | — | — | 1 | - |
| CHEMBL244168 | — | — | 1 | - |
| CHEMBL245013 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245019 | MIZORIBINE | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL243757 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL397974 | — | IC50 | = | 48700.0 | nM | 4.31 |
| CHEMBL1643 | RIBAVIRIN | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL388704 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL244381 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL388932 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL244380 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL244379 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL244169 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL388931 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL244168 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL245013 | — | IC50 | = | 108000.0 | nM | - |