GMP synthase [glutamine-hydrolyzing] · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14GMP synthase [glutamine-hydrolyzing] shows late clinical disease relevance led by lupus nephritis. 2 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P49915. Start with lupus nephritis, then reuse UniProt P49915 as the stable protein anchor across project notes and exports.
Start with lupus nephritis, then reuse UniProt P49915 as the stable protein anchor across project notes and exports.
GMP synthase [glutamine-hydrolyzing] shows late clinical disease relevance led by lupus nephritis. 2 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with lupus nephritis because it currently carries late clinical support. Linked drugs include MIZORIBINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyGMP synthase [glutamine-hydrolyzing]
Review this target as GMP synthase [glutamine-hydrolyzing], mapped to UniProt P49915. Sequence length is 693 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats GMP synthase [glutamine-hydrolyzing] as ChEMBL target CHEMBL5721, mapped to UniProt P49915. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether GMP synthase [glutamine-hydrolyzing] is the right protein anchor across sources, using UniProt P49915 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why lupus nephritis is currently framed as late clinical support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
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| Preferred Name | GMP synthase [glutamine-hydrolyzing] |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P49915 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | GMP synthase [glutamine-hydrolyzing] |
| UniProt Accession | P49915 |
| Component Type | Protein |
| Sequence Length | 693 aa |
GMP synthase [glutamine-hydrolyzing]
Review this target as GMP synthase [glutamine-hydrolyzing], mapped to UniProt P49915. Sequence length is 693 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
GMP synthase [glutamine-hydrolyzing] shows late clinical disease relevance led by lupus nephritis. 2 more disease programs remain visible in the same review block.
Start review with lupus nephritis because it currently carries late clinical support. Linked drugs include MIZORIBINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5094230 | 8.21 | IC50 | 6.2 | Preclinical |
| CHEMBL5093024 | 7.64 | IC50 | 23.0 | Preclinical |
| CHEMBL5080411 | 7.01 | IC50 | 98.0 | Preclinical |
| CHEMBL5653589 | 6.76 | Kd | 173.07 | Preclinical |
| CHEMBL453867 | 4.76 | IC50 | 17300.0 | Preclinical |
| CHEMBL1444741 | 4.33 | IC50 | 46500.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 10 | 6 | 6.5 |
| cell-based format | 2 | 0 | — |