Compound Detail
CHEMBL1541
CEFIXIME 💊 Approved Drug
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💊 Approved Drug
C=CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)/C(=N\OCC(=O)O)c3csc(N)n3)[C@H]2SC1
Basic Information
| ChEMBL ID | CHEMBL1541 |
| Name | CEFIXIME |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | OKBVVJOGVLARMR-QSWIMTSFSA-N |
| Therapeutic | ✓ Yes |
4
Targets
15
Activities
3
Assay Types
19
PK Parameters
20
Publications
17
Known Names
14
Indications
1
Mechanisms
Molecular Properties
453.5
MW (Da)
-0.54
ALogP
10
HBA
4
HBD
184.5
PSA (Ų)
0.23
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1989 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Bacterial penicillin-binding protein inhibitor | INHIBITOR | Bacterial penicillin-binding protein | ✓ | ✓ |
Indications
Bacterial Infections Bronchitis Bronchitis, Chronic Gonorrhea Infections Otitis Media Pharyngitis Tonsillitis Urinary Tract Infections HIV Infections Liver Abscess Syphilis Neoplasms Osteomyelitis
ATC Classification
J01DD08
cefixime
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIBACTERIALS FOR SYSTEMIC USE
Activity Summary
Ki 8 meas.
IC50 6 meas. best 6.12
EC50 1 meas. best 5.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.12 | 5.83 | 759.0 | 2 |
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 CHEMBL3964 | IC50 | 5.92 | 5.92 | 1212.0 | 1 |
| Apoptotic protease-activating factor 1 CHEMBL1795093 | EC50 | 5.04 | 5.04 | 9080.0 | 1 |
| ATP-binding cassette sub-family C member 2 CHEMBL5748 | IC50 | 4.05 | 4.05 | 89400.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 25000.0 | ng.hr.mL-1 | Homo sapiens |
| AUC | 9000.0 | ng.hr.mL-1 | Homo sapiens |
| AUC | 7300.0 | ng.hr.mL-1 | Homo sapiens |
| AUC | 840.0 | ng.hr.mL-1 | Homo sapiens |
| CL | 1.0 | mL.min-1.kg-1 | Homo sapiens |
| CL | 0.6 | mL.min-1.kg-1 | Homo sapiens |
| CL | 1.0 | mL.min-1.kg-1 | Homo sapiens |
| CL | 1.0 | mL.min-1.kg-1 | Homo sapiens |
| CL | 7.143 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 1.0 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 0.452 | mL.min-1.kg-1 | Homo sapiens |
| CL | 0.14 | mL.min-1.kg-1 | Homo sapiens |
| Cmax | 6615.8 | nM | Homo sapiens |
| F | 50.0 | % | Homo sapiens |
| Fu | 0.31 | - | Homo sapiens |
| Fu | 0.31 | - | Homo sapiens |
| MRT | 3.9 | hr | Homo sapiens |
| T1/2 | 3.1 | hr | Homo sapiens |
| T1/2 | 3.2 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 759.02 | nM | 6.12 | PubChem BioAssay. Counterscreen for inhibitors of LEDGF/p75-dependent integratio... | - |
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | IC50 | = | 1212.0 | nM | 5.92 | PubChem BioAssay. Counterscreen for inhibitors of phospholipase C isozymes (PLC-... | - |
| Unchecked | IC50 | = | 2892.0 | nM | 5.54 | PubChem BioAssay. TR-FRET-based biochemical high throughput dose response assay ... | - |
| Apoptotic protease-activating factor 1 | EC50 | = | 9080.0 | nM | 5.04 | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS Activators of the Apaf-1 Pa... | - |
| ATP-binding cassette sub-family C member 2 | IC50 | = | 89400.0 | nM | 4.05 | Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as... | 23956101 |
Literature References
Data from ChEMBL 36 via Core Engine