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Assay Detail

CHEMBL3214959

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
PubChem BioAssay. TR-FRET-based biochemical high throughput dose response assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration. (Class of assay: confirmatory)
ChEMBL ↗
239
Total Activities
239
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Category confirmatory
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 239 5.45 7.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL56393 — — 1 7.10
CHEMBL3190268 — — 1 6.75
CHEMBL1968928 — — 1 6.72
CHEMBL175266 — — 1 6.67
CHEMBL1601846 — — 1 6.61
CHEMBL66966 — — 1 6.56
CHEMBL1980844 — — 1 6.54
CHEMBL234338 — — 1 6.47
CHEMBL1723511 — — 1 6.43
CHEMBL1728023 — — 1 6.42
CHEMBL1508847 — — 1 6.42
CHEMBL1501392 — — 1 6.39
CHEMBL1734083 — — 1 6.37
CHEMBL3191022 — — 1 6.37
CHEMBL255881 — — 1 6.34
CHEMBL1173475 QUERCETIN DIHYDRATE — 1 6.30
CHEMBL1009 LEVODOPA 4.0 1 6.28
CHEMBL1567396 — — 1 6.24
CHEMBL1407474 — — 1 6.21
CHEMBL1985664 — — 1 6.16
CHEMBL607979 — — 1 6.16
CHEMBL1403497 — — 1 6.16
CHEMBL1730974 — — 1 6.14
CHEMBL1373655 — — 1 6.13
CHEMBL1986342 — — 1 6.13
CHEMBL164 MYRICETIN — 1 6.12
CHEMBL1527520 — — 1 6.12
CHEMBL1257003 — — 1 6.12
CHEMBL1424694 — — 1 6.10
CHEMBL1560629 — — 1 6.09

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL56393 — IC50 = 79.55 nM 7.10
CHEMBL3190268 — IC50 = 176.9 nM 6.75
CHEMBL1968928 — IC50 = 190.74 nM 6.72
CHEMBL175266 — IC50 = 211.9 nM 6.67
CHEMBL1601846 — IC50 = 243.78 nM 6.61
CHEMBL66966 — IC50 = 274.2 nM 6.56
CHEMBL1980844 — IC50 = 287.15 nM 6.54
CHEMBL234338 — IC50 = 340.9 nM 6.47
CHEMBL1723511 — IC50 = 369.19 nM 6.43
CHEMBL1728023 — IC50 = 378.31 nM 6.42
CHEMBL1508847 — IC50 = 377.24 nM 6.42
CHEMBL1501392 — IC50 = 407.79 nM 6.39
CHEMBL3191022 — IC50 = 428.69 nM 6.37
CHEMBL1734083 — IC50 = 428.67 nM 6.37
CHEMBL255881 — IC50 = 451.71 nM 6.34
CHEMBL1173475 QUERCETIN DIHYDRATE IC50 = 498.41 nM 6.30
CHEMBL1009 LEVODOPA IC50 = 526.11 nM 6.28
CHEMBL1567396 — IC50 = 575.43 nM 6.24
CHEMBL1407474 — IC50 = 619.99 nM 6.21
CHEMBL1985664 — IC50 = 689.08 nM 6.16
CHEMBL1403497 — IC50 = 690.86 nM 6.16
CHEMBL607979 — IC50 = 695.51 nM 6.16
CHEMBL1730974 — IC50 = 722.54 nM 6.14
CHEMBL1986342 — IC50 = 742.11 nM 6.13
CHEMBL1373655 — IC50 = 734.16 nM 6.13
CHEMBL164 MYRICETIN IC50 = 757.81 nM 6.12
CHEMBL1257003 — IC50 = 751.72 nM 6.12
CHEMBL1527520 — IC50 = 754.27 nM 6.12
CHEMBL1424694 — IC50 = 793.54 nM 6.10
CHEMBL3194876 — IC50 = 803.96 nM 6.09
CHEMBL1560629 — IC50 = 815.21 nM 6.09
CHEMBL1700996 — IC50 = 845.06 nM 6.07
CHEMBL3196993 — IC50 = 927.0 nM 6.03
CHEMBL1877709 — IC50 = 996.0 nM 6.00
CHEMBL3193134 — IC50 = 1023.0 nM 5.99
CHEMBL1362935 — IC50 = 1052.0 nM 5.98
CHEMBL1488474 — IC50 = 1071.0 nM 5.97
CHEMBL151 LUTEOLIN IC50 = 1059.0 nM 5.97
CHEMBL1966224 — IC50 = 1076.0 nM 5.97
CHEMBL1967046 — IC50 = 1175.0 nM 5.93
CHEMBL1401747 — IC50 = 1198.0 nM 5.92
CHEMBL1972037 — IC50 = 1244.0 nM 5.91
CHEMBL1600440 — IC50 = 1267.0 nM 5.90
CHEMBL1468796 — IC50 = 1255.0 nM 5.90
CHEMBL1429070 — IC50 = 1359.0 nM 5.87
CHEMBL1594376 — IC50 = 1354.0 nM 5.87
CHEMBL444478 ACETOSIDE IC50 = 1407.0 nM 5.85
CHEMBL1613004 — IC50 = 1478.0 nM 5.83
CHEMBL1981657 — IC50 = 1551.0 nM 5.81
CHEMBL1485960 — IC50 = 1549.0 nM 5.81