Compound Detail
CHEMBL1527520
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Basic Information
| ChEMBL ID | CHEMBL1527520 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VQPJWSZWDZNVOJ-UHFFFAOYSA-N |
10
Targets
22
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
231.2
MW (Da)
1.93
ALogP
3
HBA
3
HBD
69.6
PSA (Ų)
0.51
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 21 meas. best 6.7
EC50 1 meas. best 4.65
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein phosphatase non-receptor type 7 CHEMBL2219 | IC50 | 6.7 | 5.9833 | 200.0 | 3 |
| Unchecked CHEMBL612545 | IC50 | 6.12 | 4.6717 | 754.3 | 6 |
| NS3 CHEMBL1293269 | IC50 | 5.46 | 5.46 | 3432.0 | 1 |
| Voltage-gated N-type calcium channel alpha-1B subunit/Amyloid beta A4 precursor protein-binding family A member 1 CHEMBL2097170 | IC50 | 5.3 | 5.185 | 4980.0 | 2 |
| Tyrosine-protein phosphatase non-receptor type 22 CHEMBL2889 | IC50 | 5.17 | 5.125 | 6844.0 | 2 |
| Dual specificity protein phosphatase 6 CHEMBL5511 | IC50 | 5.13 | 5.0133 | 7380.0 | 3 |
| Envelope glycoprotein gp160 CHEMBL1293311 | IC50 | 5.01 | 5.01 | 9860.0 | 1 |
| Heat shock 70 kDa protein 1A CHEMBL5460 | IC50 | 5.01 | 5.01 | 9870.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 4.65 | 4.65 | 22610.0 | 1 |
| Glyceraldehyde-3-phosphate dehydrogenase CHEMBL2284 | IC50 | 4.32 | 4.32 | 47700.0 | 1 |
| Heat shock cognate 71 kDa protein CHEMBL1275223 | IC50 | 4.21 | 4.21 | 62000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37874947 | 10.1021/acs.jmedchem.3c01277 | Tyrosine-protein phosphatase non-receptor type 1 | 1 |
| 37874947 | 10.1021/acs.jmedchem.3c01277 | Tyrosine-protein phosphatase non-receptor type 5 | 1 |
| 37874947 | 10.1021/acs.jmedchem.3c01277 | Tyrosine-protein phosphatase non-receptor type 7 | 1 |
| 37874947 | 10.1021/acs.jmedchem.3c01277 | Receptor-type tyrosine-protein phosphatase R | 1 |
| 37874947 | 10.1021/acs.jmedchem.3c01277 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine