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Assay Detail

CHEMBL1613949

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target. Inhibition of phosphatase activity by colorimetric assay of released free phosphate (BioMol green). Secondary Screen (Class of assay: confirmatory)
ChEMBL ↗
158
Total Activities
158
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Category confirmatory
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tyrosine-protein phosphatase non-receptor type 7 (CHEMBL2219) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 158 5.61 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1360024 CEFAMANDOLE SODIUM -1.0 1 7.00
CHEMBL1527520 — — 1 6.70
CHEMBL1334633 — — 1 6.55
CHEMBL1539325 — — 1 6.40
CHEMBL1324051 — — 1 6.39
CHEMBL1376870 — — 1 6.39
CHEMBL1978364 — — 1 6.38
CHEMBL259355 — — 1 6.38
CHEMBL1353227 — — 1 6.31
CHEMBL578585 — — 1 6.16
CHEMBL1559731 — — 1 6.12
CHEMBL1334684 — — 1 6.08
CHEMBL1632 CEPHALOTHIN SODIUM 4.0 1 6.04
CHEMBL1358848 — — 1 6.00
CHEMBL1526171 — — 1 5.95
CHEMBL1384172 — — 1 5.94
CHEMBL1506716 — — 1 5.94
CHEMBL1426947 — — 1 5.93
CHEMBL1313195 — — 1 5.93
CHEMBL1577661 — — 1 5.92
CHEMBL1528814 — — 1 5.89
CHEMBL213432 — — 1 5.89
CHEMBL1305391 — — 1 5.89
CHEMBL1403497 — — 1 5.88
CHEMBL1995948 — — 1 5.85
CHEMBL1350887 — — 1 5.82
CHEMBL1465739 — — 1 5.77
CHEMBL1371869 — — 1 5.75
CHEMBL1447034 — — 1 5.67
CHEMBL1568497 — — 1 5.67

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1360024 CEFAMANDOLE SODIUM IC50 = 100.0 nM 7.00
CHEMBL1527520 — IC50 = 200.0 nM 6.70
CHEMBL1334633 — IC50 = 280.0 nM 6.55
CHEMBL1539325 — IC50 = 400.0 nM 6.40
CHEMBL1324051 — IC50 = 410.0 nM 6.39
CHEMBL1376870 — IC50 = 410.0 nM 6.39
CHEMBL1978364 — IC50 = 420.0 nM 6.38
CHEMBL259355 — IC50 = 420.0 nM 6.38
CHEMBL1353227 — IC50 = 490.0 nM 6.31
CHEMBL578585 — IC50 = 700.0 nM 6.16
CHEMBL1559731 — IC50 = 760.0 nM 6.12
CHEMBL1334684 — IC50 = 840.0 nM 6.08
CHEMBL1632 CEPHALOTHIN SODIUM IC50 = 920.0 nM 6.04
CHEMBL1358848 — IC50 = 990.0 nM 6.00
CHEMBL1526171 — IC50 = 1120.0 nM 5.95
CHEMBL1506716 — IC50 = 1150.0 nM 5.94
CHEMBL1384172 — IC50 = 1140.0 nM 5.94
CHEMBL1426947 — IC50 = 1170.0 nM 5.93
CHEMBL1313195 — IC50 = 1170.0 nM 5.93
CHEMBL1577661 — IC50 = 1210.0 nM 5.92
CHEMBL213432 — IC50 = 1300.0 nM 5.89
CHEMBL1305391 — IC50 = 1290.0 nM 5.89
CHEMBL1528814 — IC50 = 1280.0 nM 5.89
CHEMBL1403497 — IC50 = 1310.0 nM 5.88
CHEMBL1995948 — IC50 = 1400.0 nM 5.85
CHEMBL1350887 — IC50 = 1500.0 nM 5.82
CHEMBL1465739 — IC50 = 1690.0 nM 5.77
CHEMBL1371869 — IC50 = 1790.0 nM 5.75
CHEMBL1568497 — IC50 = 2120.0 nM 5.67
CHEMBL1447034 — IC50 = 2120.0 nM 5.67
CHEMBL1399711 — IC50 = 2180.0 nM 5.66
CHEMBL57978 — IC50 = 2300.0 nM 5.64
CHEMBL1337575 — IC50 = 2330.0 nM 5.63
CHEMBL571296 — IC50 = 2430.0 nM 5.61
CHEMBL1364583 — IC50 = 2540.0 nM 5.59
CHEMBL1449836 — IC50 = 2740.0 nM 5.56
CHEMBL1505300 — IC50 = 2740.0 nM 5.56
CHEMBL1481712 — IC50 = 3770.0 nM 5.42
CHEMBL1439640 — IC50 = 4020.0 nM 5.40
CHEMBL1500890 — IC50 = 4150.0 nM 5.38
CHEMBL1353989 — IC50 = 4230.0 nM 5.37
CHEMBL1449293 — IC50 = 4670.0 nM 5.33
CHEMBL1519773 — IC50 = 4660.0 nM 5.33
CHEMBL1587620 — IC50 = 4630.0 nM 5.33
CHEMBL1598822 — IC50 = 4900.0 nM 5.31
CHEMBL1477786 — IC50 = 4970.0 nM 5.30
CHEMBL1374536 — IC50 = 5270.0 nM 5.28
CHEMBL1329712 — IC50 = 5280.0 nM 5.28
CHEMBL1391256 — IC50 = 5950.0 nM 5.22
CHEMBL1575586 — IC50 = 6860.0 nM 5.16