Tyrosine-protein phosphatase non-receptor type 22 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q9Y2R2. Use UniProt Q9Y2R2 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9Y2R2 as the stable identity anchor, then attach disease evidence before program review.
Tyrosine-protein phosphatase non-receptor type 22
Review this target as Tyrosine-protein phosphatase non-receptor type 22, mapped to UniProt Q9Y2R2. Sequence length is 807 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tyrosine-protein phosphatase non-receptor type 22 as ChEMBL target CHEMBL2889, mapped to UniProt Q9Y2R2. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Tyrosine-protein phosphatase non-receptor type 22 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9Y2R2 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tyrosine-protein phosphatase non-receptor type 22 |
| UniProt Accession | Q9Y2R2 |
| Component Type | Protein |
| Sequence Length | 807 aa |
Tyrosine-protein phosphatase non-receptor type 22
Review this target as Tyrosine-protein phosphatase non-receptor type 22, mapped to UniProt Q9Y2R2. Sequence length is 807 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2396719 | 6.96 | Ki | 110.0 | Preclinical |
| CHEMBL1701224 | 6.95 | IC50 | 113.0 | Preclinical |
| CHEMBL2396718 | 6.77 | IC50 | 171.0 | Preclinical |
| CHEMBL2396719 | 6.6 | IC50 | 250.0 | Preclinical |
| CHEMBL2396723 | 6.59 | IC50 | 259.0 | Preclinical |
| CHEMBL2396720 | 6.58 | IC50 | 263.0 | Preclinical |
| CHEMBL1650888 | 6.57 | IC50 | 270.0 | Preclinical |
| CHEMBL2396717 | 6.52 | IC50 | 300.0 | Preclinical |
| CHEMBL2396721 | 6.51 | IC50 | 310.0 | Preclinical |
| CHEMBL1650889 | 6.47 | IC50 | 340.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 41 | 26 | 5.2 |
| single protein format | 37 | 119 | 5.3 |
| assay format | 30 | 102 | 5.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 10 | 84 | 5.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 4 | 1 | 5.3 |
| assay format | 1 | 0 | — |