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Compound Detail

CHEMBL1200343

PERINDOPRIL ERBUMINE
💊 Approved Drug
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💊 Approved Drug
CC(C)(C)N.CCC[C@H](N[C@@H](C)C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21)C(=O)OCC
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1200343
Name PERINDOPRIL ERBUMINE
Phase Approved
Structure Type MOL
InChI Key IYNMDWMQHSMDDE-MHXJNQAMSA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL1581
Active Moiety CHEMBL1201368

Known Names

Aceon Coversyl MCN-A-2833-109 NSC-758929 Perindopril erbumine Perindopril erbumine component of amlessa Perindopril tert-butylamine S-9490-3
0
Targets
0
Activities
0
Assay Types
4
PK Parameters
9
Publications
8
Known Names
4
Indications
1
Mechanisms

Molecular Properties

368.5
MW (Da)
1.94
ALogP
5
HBA
2
HBD
95.9
PSA (Ų)
0.64
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1993
Availability Prescription
Chirality Single Enantiomer

Routes of Administration

Oral

Flags

Black Box Warning Prodrug
USAN Stem -pril
USAN Year 1989

Extended Properties

Molecular Formula C23H43N3O5
MW 441.61
Aromatic Rings 0
Heavy Atoms 26
NP-Likeness 0.08

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Angiotensin-converting enzyme inhibitor INHIBITOR Angiotensin-converting enzyme ✓ ✓

Indications

Coronary Artery Disease Hypertension Myocardial Infarction Essential Hypertension

Drug Warnings

Black Box Warning
teratogenicity
Country: United States

Pharmacokinetic Data

Parameter Value Units Species
F 75.0 % Homo sapiens
PPB 60.0 % Homo sapiens
T1/2 0.8 hr Homo sapiens
Tmax 1.0 hr Homo sapiens

Literature References

PubMed DOI Target Context # Activities
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B3 1
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B1 1
23956101 10.1093/toxsci/kft176 Bile salt export pump 1
23956101 10.1093/toxsci/kft176 ATP-binding cassette sub-family C member 2 1
23956101 10.1093/toxsci/kft176 ATP-binding cassette sub-family C member 3 1
23956101 10.1093/toxsci/kft176 ATP-binding cassette sub-family C member 4 1
- 10.21203/rs.3.rs-23951/v1 SARS-CoV-2 1
- 10.6019/CHEMBL4495564 Replicase polyprotein 1ab 1

Data from ChEMBL 36 via Core Engine