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Compound Detail

CHEMBL1201161

MAFENIDE ACETATE
💊 Approved Drug
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💊 Approved Drug
CC(=O)O.NCc1ccc(S(N)(=O)=O)cc1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1201161
Name MAFENIDE ACETATE
Phase Approved
Structure Type MOL
InChI Key UILOTUUZKGTYFQ-UHFFFAOYSA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL419
Active Moiety CHEMBL419

Known Names

Mafenide acetate Sulfamylon
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
12
Publications
2
Known Names
3
Indications
1
Mechanisms

Molecular Properties

186.2
MW (Da)
-0.21
ALogP
3
HBA
2
HBD
86.2
PSA (Ų)
0.67
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1969
Availability Prescription
Chirality Achiral

Routes of Administration

Topical

Extended Properties

Molecular Formula C9H14N2O4S
MW 246.29
Aromatic Rings 1
Heavy Atoms 12
NP-Likeness -1.14

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Bacterial dihydropteroate synthase inhibitor INHIBITOR Dihydropteroate synthase ✓ ✓

Indications

Bacterial Infections Burns Osteomyelitis

Literature References

PubMed DOI Target Context # Activities
22194678 10.1371/journal.pcbi.1002310 Hepatotoxicity 14
23956101 10.1093/toxsci/kft176 Bile salt export pump 1
23956101 10.1093/toxsci/kft176 ATP-binding cassette sub-family C member 2 1
23956101 10.1093/toxsci/kft176 ATP-binding cassette sub-family C member 3 1
23956101 10.1093/toxsci/kft176 ATP-binding cassette sub-family C member 4 1
- 10.6019/CHEMBL4513141 Candida albicans 1
- 10.6019/CHEMBL4513141 Cryptococcus neoformans 1
- 10.6019/CHEMBL4513141 Escherichia coli 1
- 10.6019/CHEMBL4513141 Klebsiella pneumoniae 1
- 10.6019/CHEMBL4513141 Pseudomonas aeruginosa 1
- 10.6019/CHEMBL4513141 Acinetobacter baumannii 1
- 10.6019/CHEMBL4513141 Staphylococcus aureus 1

Data from ChEMBL 36 via Core Engine