Compound Detail
CHEMBL719
MUPIROCIN 💊 Approved Drug
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💊 Approved Drug
C/C(=C\C(=O)OCCCCCCCCC(=O)O)C[C@@H]1OC[C@H](C[C@@H]2O[C@H]2[C@@H](C)[C@H](C)O)[C@@H](O)[C@H]1O
Basic Information
| ChEMBL ID | CHEMBL719 |
| Name | MUPIROCIN |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | MINDHVHHQZYEEK-HBBNESRFSA-N |
| Therapeutic | ✓ Yes |
5
Targets
14
Activities
3
Assay Types
0
PK Parameters
20
Publications
12
Known Names
12
Indications
2
Mechanisms
Molecular Properties
500.6
MW (Da)
2.59
ALogP
8
HBA
4
HBD
146.1
PSA (Ų)
0.11
QED
1
Ro5 Violations
16
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1987 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Isoleucyl-tRNA synthetase inhibitor | INHIBITOR | Isoleucine--tRNA ligase | ✓ | ✓ |
| Isoleucyl-tRNA synthetase inhibitor | INHIBITOR | Isoleucine--tRNA ligase | ✓ | ✓ |
Indications
Impetigo Nasal Obstruction Epistaxis Infections Staphylococcal Infections Telangiectasia, Hereditary Hemorrhagic Cystic Fibrosis Hemangioma Radiodermatitis Sinusitis Bacterial Infections Osteomyelitis
ATC Classification
D06AX09
mupirocin
Level 1: DERMATOLOGICALS
Level 2: ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
R01AX06
mupirocin
Level 1: RESPIRATORY SYSTEM
Level 2: NASAL PREPARATIONS
Activity Summary
IC50 7 meas. best 9.1
Ki 6 meas. best 8.6
EC50 1 meas. best 6.37
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Isoleucine--tRNA ligase, cytoplasmic CHEMBL3235 | IC50 | 9.1 | 9.1 | 0.8 | 1 |
| Isoleucine--tRNA ligase CHEMBL3657 | Ki | 8.6 | 8.6 | 2.5 | 1 |
| Isoleucine--tRNA ligase CHEMBL3879837 | Ki | 7.22 | 5.968 | 60.0 | 5 |
| Streptokinase A CHEMBL1293228 | EC50 | 6.37 | 6.37 | 423.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.01 | 4.8167 | 9670.0 | 6 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine