Isoleucine--tRNA ligase · SINGLE PROTEIN · Escherichia coli K-12
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As of 2026-09-14Protein identity stays anchored to UniProt P00956. Use UniProt P00956 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P00956 as the stable identity anchor, then attach disease evidence before program review.
Isoleucine--tRNA ligase
Review this target as Isoleucine--tRNA ligase, mapped to UniProt P00956. Sequence length is 938 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Isoleucine--tRNA ligase as ChEMBL target CHEMBL3657, mapped to UniProt P00956. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Isoleucine--tRNA ligase is the right protein anchor across sources, using UniProt P00956 as the stable mapping.
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| Preferred Name | Isoleucine--tRNA ligase |
| Target Type | SINGLE PROTEIN |
| Organism | Escherichia coli K-12 |
| UniProt | P00956 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Isoleucine--tRNA ligase |
| UniProt Accession | P00956 |
| Component Type | Protein |
| Sequence Length | 938 aa |
Isoleucine--tRNA ligase
Review this target as Isoleucine--tRNA ligase, mapped to UniProt P00956. Sequence length is 938 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4553017 | 8.92 | Ki | 1.2 | Preclinical |
| CHEMBL1163069 | 8.72 | Ki | 1.92 | Preclinical |
| CHEMBL719 | 8.6 | Ki | 2.5 | Approved |
| CHEMBL4553017 | 8.17 | IC50 | 6.8 | Preclinical |
| CHEMBL3265242 | 7.76 | Ki | 17.2 | Preclinical |
| CHEMBL3265243 | 7.26 | Ki | 55.0 | Preclinical |
| CHEMBL4636583 | 7.06 | Ki | 88.0 | Preclinical |
| CHEMBL4648043 | 6.94 | Ki | 114.0 | Preclinical |
| CHEMBL4215986 | 6.67 | Ki | 213.0 | Preclinical |
| CHEMBL1163069 | 6.58 | IC50 | 265.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 14 | 4 | 7.9 |
| single protein format | 11 | 8 | 6.6 |