Isoleucine--tRNA ligase, cytoplasmic · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P41252. Use UniProt P41252 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P41252 as the stable identity anchor, then attach disease evidence before program review.
Isoleucine--tRNA ligase, cytoplasmic
Review this target as Isoleucine--tRNA ligase, cytoplasmic, mapped to UniProt P41252. Sequence length is 1262 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Isoleucine--tRNA ligase, cytoplasmic as ChEMBL target CHEMBL3235, mapped to UniProt P41252. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Isoleucine--tRNA ligase, cytoplasmic |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P41252 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Isoleucine--tRNA ligase, cytoplasmic |
| UniProt Accession | P41252 |
| Component Type | Protein |
| Sequence Length | 1262 aa |
Isoleucine--tRNA ligase, cytoplasmic
Review this target as Isoleucine--tRNA ligase, cytoplasmic, mapped to UniProt P41252. Sequence length is 1262 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL719 | 9.1 | IC50 | 0.8 | Approved |
| CHEMBL605376 | 7.85 | IC50 | 14.0 | Preclinical |
| CHEMBL125075 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL340359 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL125820 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL538163 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL605592 | 7.41 | IC50 | 39.0 | Preclinical |
| CHEMBL125221 | 7.35 | IC50 | 45.0 | Preclinical |
| CHEMBL3752910 | 7.03 | Kd | 94.41 | Preclinical |
| CHEMBL1163069 | 7.01 | IC50 | 98.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 9 | 42 | 6.0 |
| cell-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 4 | 0 | — |