Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL605592

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
C#Cc1nc(N)c2ncn(C3O[C@H](COS(=O)(=O)NC(=O)[C@@H](N)[C@@H](C)CC)[C@@H](O)[C@H]3O)c2n1

Basic Information

ChEMBL ID CHEMBL605592
Phase Preclinical
Structure Type MOL
InChI Key SSGGLIACHXJUIJ-HFCNYBATSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

483.5
MW (Da)
-2.24
ALogP
13
HBA
5
HBD
217.8
PSA (Ų)
0.25
QED
1
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H25N7O7S
MW 483.51
Aromatic Rings 2
Heavy Atoms 33
NP-Likeness 0.58

Activity Summary

IC50 1 meas. best 7.41

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Isoleucine--tRNA ligase, cytoplasmic
CHEMBL3235
IC50 7.41 7.41 39.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
12643918 10.1016/s0960-894x(03)00020-9 Isoleucine--tRNA ligase, cytoplasmic 1

Data from ChEMBL 36 via Core Engine