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Assay Detail

CHEMBL4270097

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC BAA-44 after 6 to 8 hrs by bacterial proliferation assay
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Staphylococcus aureus
Confidence 1 — Organism
Curated By Intermediate

Target

Staphylococcus aureus (CHEMBL352)
Type ORGANISM
Organism Staphylococcus aureus

Publication

Hydroxybiphenylamide GroEL/ES Inhibitors Are Potent Antibacterials against Planktonic and Biofilm Forms of Staphylococcus aureus.
Kunkle T, Abdeen S, Salim N, Ray AM, Stevens M, Ambrose AJ, Victorino J, Park Y, Hoang QQ, Chapman E, Johnson SM.
J Med Chem (2018) 61 : 10651 -10664
PubMed 30392371 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 50 5.89 6.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4291977 1 6.85
CHEMBL4283280 1 6.77
CHEMBL374478 RIFAMPIN 4.0 1 6.64
CHEMBL287542 RAFOXANIDE 2.0 1 6.47
CHEMBL4277902 1 6.39
CHEMBL4284769 1 6.35
CHEMBL12131 CLOSANTEL 2.0 1 6.33
CHEMBL4277733 1 6.28
CHEMBL262777 VANCOMYCIN 4.0 1 6.28
CHEMBL4285206 1 6.28
CHEMBL1632145 1 6.26
CHEMBL4293874 1 6.15
CHEMBL387675 DAPTOMYCIN 4.0 1 6.00
CHEMBL4281358 1 5.96
CHEMBL1631668 1 5.96
CHEMBL4293036 1 5.70
CHEMBL1801800 METABROMSALAN 4.0 1 5.70
CHEMBL4294873 1 5.39
CHEMBL460481 1 5.38
CHEMBL4286965 1 5.00
CHEMBL4289991 1 4.92
CHEMBL82970 SALICYLANILIDE -1.0 1 4.29
CHEMBL4287756 1 4.17
CHEMBL4287938 1 -
CHEMBL4282049 1 -
CHEMBL4282354 1 -
CHEMBL4291342 1 -
CHEMBL4295129 1 -
CHEMBL4284817 1 -
CHEMBL4292443 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4291977 EC50 = 140.0 nM 6.85
CHEMBL4283280 EC50 = 170.0 nM 6.77
CHEMBL374478 RIFAMPIN EC50 = 230.0 nM 6.64
CHEMBL287542 RAFOXANIDE EC50 = 340.0 nM 6.47
CHEMBL4277902 EC50 = 410.0 nM 6.39
CHEMBL4284769 EC50 = 450.0 nM 6.35
CHEMBL12131 CLOSANTEL EC50 = 470.0 nM 6.33
CHEMBL4277733 EC50 = 520.0 nM 6.28
CHEMBL262777 VANCOMYCIN EC50 = 520.0 nM 6.28
CHEMBL4285206 EC50 = 530.0 nM 6.28
CHEMBL1632145 EC50 = 550.0 nM 6.26
CHEMBL4293874 EC50 = 710.0 nM 6.15
CHEMBL387675 DAPTOMYCIN EC50 = 1000.0 nM 6.00
CHEMBL4281358 EC50 = 1100.0 nM 5.96
CHEMBL1631668 EC50 = 1100.0 nM 5.96
CHEMBL4293036 EC50 = 2000.0 nM 5.70
CHEMBL1801800 METABROMSALAN EC50 = 2000.0 nM 5.70
CHEMBL4294873 EC50 = 4100.0 nM 5.39
CHEMBL460481 EC50 = 4200.0 nM 5.38
CHEMBL4286965 EC50 = 10000.0 nM 5.00
CHEMBL4289991 EC50 = 12000.0 nM 4.92
CHEMBL82970 SALICYLANILIDE EC50 = 51000.0 nM 4.29
CHEMBL4287756 EC50 = 68000.0 nM 4.17
CHEMBL4293780 EC50 > 100000.0 nM -
CHEMBL4292652 EC50 > 100000.0 nM -
CHEMBL4285476 EC50 > 100000.0 nM -
CHEMBL4281802 EC50 > 100000.0 nM -
CHEMBL4288844 EC50 > 100000.0 nM -
CHEMBL115523 N-PHENYLBENZAMIDE EC50 > 100000.0 nM -
CHEMBL4292251 EC50 > 100000.0 nM -
CHEMBL494463 EC50 > 100000.0 nM -
CHEMBL1559759 EC50 > 100000.0 nM -
CHEMBL4282114 EC50 > 100000.0 nM -
CHEMBL4286566 EC50 > 100000.0 nM -
CHEMBL4278650 EC50 > 100000.0 nM -
CHEMBL4283202 EC50 > 100000.0 nM -
CHEMBL4280410 EC50 > 100000.0 nM -
CHEMBL174 AMPICILLIN EC50 > 100000.0 nM -
CHEMBL4279725 EC50 > 100000.0 nM -
CHEMBL2046765 EC50 > 100000.0 nM -
CHEMBL4292831 EC50 > 100000.0 nM -
CHEMBL4282229 EC50 > 100000.0 nM -
CHEMBL4286707 EC50 > 100000.0 nM -
CHEMBL4292443 EC50 > 100000.0 nM -
CHEMBL4284817 EC50 > 100000.0 nM -
CHEMBL4295129 EC50 > 100000.0 nM -
CHEMBL4291342 EC50 > 100000.0 nM -
CHEMBL4282354 EC50 > 100000.0 nM -
CHEMBL4282049 EC50 > 100000.0 nM -
CHEMBL4287938 EC50 > 100000.0 nM -