Compound Detail
CHEMBL1384
KANAMYCIN 💊 Approved Drug
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💊 Approved Drug
NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O
Basic Information
| ChEMBL ID | CHEMBL1384 |
| Name | KANAMYCIN |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | SBUJHOSQTJFQJX-NOAMYHISSA-N |
| Therapeutic | ✓ Yes |
14
Targets
30
Activities
3
Assay Types
4
PK Parameters
20
Publications
4
Known Names
5
Indications
Molecular Properties
484.5
MW (Da)
-7.29
ALogP
15
HBA
11
HBD
282.6
PSA (Ų)
0.17
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1973 |
| Availability | Discontinued |
| Chirality | Single Enantiomer |
Indications
Bacterial Infections Eye Infections Tuberculosis Tuberculosis, Multidrug-Resistant Osteomyelitis
ATC Classification
A07AA08
kanamycin
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
J01GB04
kanamycin
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIBACTERIALS FOR SYSTEMIC USE
S01AA24
kanamycin
Level 1: SENSORY ORGANS
Level 2: OPHTHALMOLOGICALS
Activity Summary
IC50 20 meas. best 7.52
EC50 5 meas. best 5.09
Kd 5 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Escherichia coli CHEMBL354 | IC50 | 7.52 | 6.902 | 30.0 | 5 |
| Pseudomonas aeruginosa CHEMBL348 | IC50 | 7.31 | 7.31 | 49.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 7.1 | 5.745 | 80.0 | 4 |
| Ribosomal RNA A-site CHEMBL614640 | IC50 | 7.0 | 7.0 | 100.0 | 1 |
| microRNA 21 CHEMBL1615322 | Kd | 7.0 | 7.0 | 100.0 | 1 |
| Bacillus subtilis CHEMBL359 | IC50 | 6.87 | 6.87 | 135.0 | 1 |
| Staphylococcus aureus CHEMBL352 | IC50 | 6.52 | 6.52 | 300.0 | 1 |
| microRNA 21 CHEMBL1615322 | IC50 | 5.96 | 5.96 | 1102.0 | 1 |
| Nucleic Acid CHEMBL345 | Kd | 5.68 | 5.3975 | 2080.0 | 4 |
| Beta-ketoacyl-[acyl-carrier-protein] synthase III CHEMBL4914 | IC50 | 5.17 | 5.17 | 6800.0 | 1 |
| Staphylococcus aureus CHEMBL352 | EC50 | 5.09 | 5.09 | 8200.0 | 1 |
| Gap junction beta-2 protein CHEMBL4295738 | IC50 | 5.03 | 4.985 | 9400.0 | 2 |
| Acinetobacter baumannii CHEMBL614425 | EC50 | 4.8 | 4.8 | 16000.0 | 1 |
| Pseudomonas aeruginosa CHEMBL348 | EC50 | 4.6 | 4.6 | 25000.0 | 1 |
| Enterobacter cloacae CHEMBL349 | EC50 | 4.43 | 4.43 | 37000.0 | 1 |
| Klebsiella pneumoniae subsp. pneumoniae CHEMBL613207 | EC50 | 4.35 | 4.35 | 45000.0 | 1 |
| Gap junction alpha-1 protein CHEMBL4680024 | IC50 | 4.32 | 4.32 | 48000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 1.4 | mL.min-1.kg-1 | Homo sapiens |
| Fu | 0.99 | - | Homo sapiens |
| MRT | 3.1 | hr | Homo sapiens |
| T1/2 | 2.1 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine