Assay Detail
Binding
CHEMBL3386957
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli FabH
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Beta-ketoacyl-[acyl-carrier-protein] synthase III (CHEMBL4914) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli K-12 |
Publication
Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.04 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3352863 | — | — | 1 | 5.31 |
| CHEMBL3357052 | — | — | 1 | 5.28 |
| CHEMBL3357053 | — | — | 1 | 5.21 |
| CHEMBL3357054 | — | — | 1 | 5.21 |
| CHEMBL1384 | KANAMYCIN | 4.0 | 1 | 5.17 |
| CHEMBL3357055 | — | — | 1 | 5.14 |
| CHEMBL3357056 | — | — | 1 | 5.07 |
| CHEMBL3357057 | — | — | 1 | 5.04 |
| CHEMBL3357059 | — | — | 1 | 4.87 |
| CHEMBL3357058 | — | — | 1 | 4.68 |
| CHEMBL3357562 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3352863 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL3357052 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3357053 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3357054 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL1384 | KANAMYCIN | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL3357055 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL3357056 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL3357057 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL3357059 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL3357058 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL3357562 | — | IC50 | = | 36200.0 | nM | 4.44 |