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Assay Detail

CHEMBL678816

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Functional
Inhibition of cell free transcription/translation by Escherichia coli s30 bacterial extract.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Escherichia coli
Confidence 1 — Organism
Curated By Expert

Target

Escherichia coli (CHEMBL354)
Type ORGANISM
Organism Escherichia coli

Publication

New inhibitors of bacterial protein synthesis from a combinatorial library of macrocycles.
Jefferson EA, Arakawa S, Blyn LB, Miyaji A, Osgood SA, Ranken R, Risen LM, Swayze EE.
J Med Chem (2002) 45 : 3430 -3439
PubMed 12139453 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 4.87 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1384 KANAMYCIN 4.0 1 7.40
CHEMBL334284 1 5.70
CHEMBL115185 1 5.52
CHEMBL116346 1 4.92
CHEMBL325265 1 4.82
CHEMBL114170 1 4.80
CHEMBL113977 1 4.77
CHEMBL325487 1 4.70
CHEMBL113875 1 4.60
CHEMBL326569 1 4.48
CHEMBL325902 1 4.40
CHEMBL113823 1 4.30
CHEMBL116617 1 4.30
CHEMBL117489 1 4.21
CHEMBL333837 1 4.12
CHEMBL323883 1 -
CHEMBL116397 1 -
CHEMBL431079 1 -
CHEMBL116877 1 -
CHEMBL117544 1 -
CHEMBL428621 1 -
CHEMBL118057 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1384 KANAMYCIN IC50 = 40.0 nM 7.40
CHEMBL334284 IC50 = 2000.0 nM 5.70
CHEMBL115185 IC50 = 3000.0 nM 5.52
CHEMBL116346 IC50 = 12000.0 nM 4.92
CHEMBL325265 IC50 = 15000.0 nM 4.82
CHEMBL114170 IC50 = 16000.0 nM 4.80
CHEMBL113977 IC50 = 17000.0 nM 4.77
CHEMBL325487 IC50 = 20000.0 nM 4.70
CHEMBL113875 IC50 = 25000.0 nM 4.60
CHEMBL326569 IC50 = 33000.0 nM 4.48
CHEMBL325902 IC50 = 40000.0 nM 4.40
CHEMBL113823 IC50 = 50000.0 nM 4.30
CHEMBL116617 IC50 = 50000.0 nM 4.30
CHEMBL117489 IC50 = 62000.0 nM 4.21
CHEMBL333837 IC50 = 75000.0 nM 4.12
CHEMBL323883 IC50 > 100000.0 nM -
CHEMBL116397 IC50 > 100000.0 nM -
CHEMBL431079 IC50 > 100000.0 nM -
CHEMBL116877 IC50 > 100000.0 nM -
CHEMBL117544 IC50 > 100000.0 nM -
CHEMBL428621 IC50 > 100000.0 nM -
CHEMBL118057 IC50 > 100000.0 nM -