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Evidence Snapshot

Escherichia coli

CHEMBL354 ORGANISM Escherichia coli
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T17:40:44Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL354
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Escherichia coli as ChEMBL target CHEMBL354. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Escherichia coli
ORGANISM · Escherichia coli
As of 2026-09-13
ChEMBL target ID
CHEMBL354
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Escherichia coli matters

As of 2026-09-13

Escherichia coli is reviewed as Escherichia coli; the current evidence base includes 33 approved drugs, 69770 compounds, and 18624 assays, with lead potency reaching pChEMBL 10.5.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 33 approved drugs, 69770 compounds, and 18624 assays for this target. The dominant activity type is IC50. CHEMBL18925 is the current potency anchor at pChEMBL 10.5.

Use CHEMBL18925 as the tractability anchor when discussing potency (pChEMBL 10.5).

Activity source · ChEMBL 36 via Core Engine
33 approved pChEMBL 10.5
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Escherichia coli matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

69770
Total Compounds
18624
Total Assays
33
Approved Drugs
IC50: 2639.0, KI: 16.0, EC50: 276.0, KD: 27.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL18925
 10.5 Ki —
No preferred name
CHEMBL4289275
 10.4 EC50 —
No preferred name
CHEMBL19227
 10.1 Ki —
No preferred name
CHEMBL376180
 10.1 Ki Clinical
No preferred name
CHEMBL405688
 9.5 Kd —

Approved Drugs

Structure Compound First Approval
LINEZOLID
CHEMBL126
 2000
TRICLOSAN
CHEMBL849
 1997
MEROPENEM
CHEMBL127
 1996
LEVOFLOXACIN
CHEMBL5315124
 1996
CIPROFLOXACIN
CHEMBL8
 1987
IMIPENEM ANHYDROUS
CHEMBL148
 1985
CLAVULANIC ACID
CHEMBL777
 1984
CEFTRIAXONE
CHEMBL161
 1984
CEFOTAXIME
CHEMBL1730
 1981
ETIDRONIC ACID
CHEMBL871
 1977
TOBRAMYCIN
CHEMBL1747
 1975
TRIMETHOPRIM
CHEMBL22
 1973
KANAMYCIN
CHEMBL1384
 1973
SPECTINOMYCIN
CHEMBL1167
 1971
PAROMOMYCIN
CHEMBL370143
 1969
DOXYCYCLINE
CHEMBL1200699
 1967
AMPICILLIN
CHEMBL174
 1965
ERYTHROMYCIN
CHEMBL532
 1964
VANCOMYCIN
CHEMBL262777
 1964
NITROFURANTOIN
CHEMBL572
 1953
CHLORAMPHENICOL
CHEMBL130
 1950
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T17:40:44Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL354