Compound Detail
CHEMBL370143
PAROMOMYCIN 💊 Approved Drug
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💊 Approved Drug
NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O
Basic Information
| ChEMBL ID | CHEMBL370143 |
| Name | PAROMOMYCIN |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | UOZODPSAJZTQNH-LSWIJEOBSA-N |
| Therapeutic | ✓ Yes |
13
Targets
64
Activities
3
Assay Types
1
PK Parameters
20
Publications
19
Known Names
4
Indications
Molecular Properties
615.6
MW (Da)
-8.86
ALogP
19
HBA
13
HBD
347.3
PSA (Ų)
0.11
QED
3
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1969 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Indications
Leishmaniasis, Cutaneous Leishmaniasis, Visceral Leishmaniasis Osteomyelitis
ATC Classification
A07AA06
paromomycin
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
Activity Summary
IC50 33 meas. best 7.48
Kd 24 meas. best 8.3
EC50 7 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | Kd | 8.3 | 5.6971 | 5.0 | 7 |
| Leishmania donovani CHEMBL367 | EC50 | 8.3 | 7.21 | 5.0 | 3 |
| Bacterial 70S ribosome CHEMBL2363135 | IC50 | 7.48 | 7.45 | 33.0 | 2 |
| Escherichia coli CHEMBL354 | IC50 | 7.25 | 7.25 | 56.0 | 1 |
| Ribosomal RNA A-site CHEMBL614640 | Kd | 7.0 | 6.7033 | 100.0 | 3 |
| No relevant target CHEMBL2362975 | Kd | 6.7 | 6.7 | 200.0 | 1 |
| Nucleic Acid CHEMBL345 | Kd | 6.4 | 5.66 | 400.0 | 9 |
| Nucleic Acid CHEMBL345 | IC50 | 6.22 | 6.22 | 600.0 | 1 |
| Cryptosporidium parvum CHEMBL612855 | IC50 | 6.15 | 6.15 | 711.0 | 1 |
| Leishmania major CHEMBL612879 | EC50 | 5.4 | 5.385 | 3980.0 | 2 |
| Unchecked CHEMBL612545 | IC50 | 4.92 | 4.695 | 12000.0 | 4 |
| Leishmania amazonensis CHEMBL612877 | IC50 | 4.72 | 4.72 | 19000.0 | 1 |
| Leishmania donovani CHEMBL367 | IC50 | 4.71 | 4.4714 | 19700.0 | 7 |
| Trypanosoma brucei rhodesiense CHEMBL612348 | EC50 | 4.64 | 4.64 | 22700.0 | 1 |
| Leishmania major CHEMBL612879 | IC50 | 4.6 | 4.6 | 25000.0 | 1 |
| Leishmania infantum CHEMBL612848 | IC50 | 4.37 | 4.184 | 42410.0 | 5 |
| Bacillus subtilis CHEMBL359 | Kd | 4.3 | 4.3 | 50000.0 | 1 |
| Cryptosporidium parvum CHEMBL612855 | EC50 | 4.19 | 4.19 | 65000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Ka | 3.9 | 10'-5/M | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine