Assay Detail
Binding
CHEMBL911513
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Binding affinity to bacterial ribosomal A site RNA oligonucleotide
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Expert |
Publication
Binding of aminoglycosidic antibiotics to the oligonucleotide A-site model and 30S ribosomal subunit: Poisson-Boltzmann model, thermal denaturation, and fluorescence studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 5.29 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370143 | PAROMOMYCIN | 4.0 | 1 | 6.41 |
| CHEMBL384124 | GENTAMICIN C | — | 1 | 5.26 |
| CHEMBL427409 | NEAMINE | — | 1 | 5.13 |
| CHEMBL215226 | GENETICIN | — | 1 | 4.84 |
| CHEMBL221572 | RIBOSTAMYCIN | 2.0 | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370143 | PAROMOMYCIN | Kd | = | 390.0 | nM | 6.41 |
| CHEMBL384124 | GENTAMICIN C | Kd | = | 5530.0 | nM | 5.26 |
| CHEMBL427409 | NEAMINE | Kd | = | 7390.0 | nM | 5.13 |
| CHEMBL215226 | GENETICIN | Kd | = | 14520.0 | nM | 4.84 |
| CHEMBL221572 | RIBOSTAMYCIN | Kd | = | 16350.0 | nM | 4.79 |