Compound Detail
CHEMBL221572
RIBOSTAMYCIN 🧪 Phase II
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🧪 Phase II
NC[C@H]1O[C@H](O[C@H]2[C@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)[C@@H](O)[C@H](N)C[C@@H]2N)[C@H](N)[C@@H](O)[C@@H]1O
Basic Information
| ChEMBL ID | CHEMBL221572 |
| Name | RIBOSTAMYCIN |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | NSKGQURZWSPSBC-VVPCINPTSA-N |
2
Targets
5
Activities
2
Assay Types
3
PK Parameters
20
Publications
4
Known Names
1
Indications
Molecular Properties
454.5
MW (Da)
-6.65
ALogP
14
HBA
10
HBD
262.4
PSA (Ų)
0.18
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Indications
Bacterial Infections
ATC Classification
J01GB10
ribostamycin
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIBACTERIALS FOR SYSTEMIC USE
Activity Summary
Kd 3 meas. best 5.77
IC50 2 meas. best 7.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ribosomal RNA A-site CHEMBL614640 | IC50 | 7.05 | 7.05 | 90.0 | 1 |
| Nucleic Acid CHEMBL345 | Kd | 5.77 | 5.77 | 1700.0 | 1 |
| Ribosomal RNA A-site CHEMBL614640 | Kd | 4.79 | 4.695 | 16350.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 1.5 | mL.min-1.kg-1 | Homo sapiens |
| MRT | 2.8 | hr | Homo sapiens |
| T1/2 | 2.5 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ribosomal RNA A-site | IC50 | = | 90.0 | nM | 7.05 | Binding affinity to 16S rRNA A-site in Escherichia coli S30 extract assessed as ... | 27509271 |
| Nucleic Acid | Kd | = | 1700.0 | nM | 5.77 | Binding affinity to A-site RNA | 19445516 |
| Ribosomal RNA A-site | Kd | = | 16350.0 | nM | 4.79 | Binding affinity to bacterial ribosomal A site RNA oligonucleotide | 16942021 |
| Ribosomal RNA A-site | Kd | = | 25000.0 | nM | 4.6 | Binding affinity of aminoglycoside to 16S ribosomal RNA A-site in Escherichia co... | 11206440 |
Literature References
Data from ChEMBL 36 via Core Engine