Assay Detail
Binding
CHEMBL615153
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Binding affinity of aminoglycoside to 16S ribosomal RNA A-site in Escherichia coli
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Expert |
Publication
Which aminoglycoside ring is most important for binding? A hydropathic analysis of gentamicin, paromomycin, and analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 14 | 5.69 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184618 | FRAMYCETIN | 3.0 | 1 | 7.72 |
| CHEMBL370143 | PAROMOMYCIN | 4.0 | 1 | 6.70 |
| CHEMBL606550 | — | — | 1 | 6.58 |
| CHEMBL1159506 | — | — | 1 | 6.16 |
| CHEMBL176 | BEKANAMYCIN | 3.0 | 1 | 5.85 |
| CHEMBL1747 | TOBRAMYCIN | 4.0 | 1 | 5.82 |
| CHEMBL1159782 | — | — | 1 | 5.77 |
| CHEMBL301721 | GENTAMICIN C1A | — | 1 | 5.77 |
| CHEMBL427409 | NEAMINE | — | 1 | 5.11 |
| CHEMBL223520 | KANAMYCIN A | 1.0 | 1 | 4.75 |
| CHEMBL221572 | RIBOSTAMYCIN | 2.0 | 1 | 4.60 |
| CHEMBL605012 | BUTIROSIN B | — | 1 | 4.57 |
| CHEMBL606551 | — | — | 1 | 4.55 |
| CHEMBL606552 | PAROMAMINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184618 | FRAMYCETIN | Kd | = | 19.0 | nM | 7.72 |
| CHEMBL370143 | PAROMOMYCIN | Kd | = | 200.0 | nM | 6.70 |
| CHEMBL606550 | — | Kd | = | 260.0 | nM | 6.58 |
| CHEMBL1159506 | — | Kd | = | 700.0 | nM | 6.16 |
| CHEMBL176 | BEKANAMYCIN | Kd | = | 1400.0 | nM | 5.85 |
| CHEMBL1747 | TOBRAMYCIN | Kd | = | 1500.0 | nM | 5.82 |
| CHEMBL1159782 | — | Kd | = | 1700.0 | nM | 5.77 |
| CHEMBL301721 | GENTAMICIN C1A | Kd | = | 1700.0 | nM | 5.77 |
| CHEMBL427409 | NEAMINE | Kd | = | 7800.0 | nM | 5.11 |
| CHEMBL223520 | KANAMYCIN A | Kd | = | 18000.0 | nM | 4.75 |
| CHEMBL221572 | RIBOSTAMYCIN | Kd | = | 25000.0 | nM | 4.60 |
| CHEMBL605012 | BUTIROSIN B | Kd | = | 27000.0 | nM | 4.57 |
| CHEMBL606551 | — | Kd | = | 28000.0 | nM | 4.55 |
| CHEMBL606552 | PAROMAMINE | Kd | < | 100000.0 | nM | - |