Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL223520

KANAMYCIN A
Phase I
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
Phase I
NC[C@@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@@H](O)[C@H](O)[C@H]1O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL223520
Name KANAMYCIN A
Phase Phase I
Structure Type MOL
InChI Key SBUJHOSQTJFQJX-KSACQAOKSA-N

Known Names

Kanamycin a
3
Targets
8
Activities
3
Assay Types
0
PK Parameters
20
Publications
1
Known Names

Molecular Properties

484.5
MW (Da)
-7.29
ALogP
15
HBA
11
HBD
282.6
PSA (Ų)
0.17
QED
2
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Single Enantiomer

Flags

Natural Product
USAN Stem -mycin

Extended Properties

Molecular Formula C18H36N4O11
MW 484.50
Aromatic Rings 0
Heavy Atoms 33
NP-Likeness 1.56

Activity Summary

Kd 4 meas. best 7.0
EC50 2 meas. best 6.52
IC50 2 meas. best 7.62

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
 IC50 7.62 6.185 24.0 2
Nucleic Acid
CHEMBL345
 Kd 7.0 7.0 100.0 1
Nucleic Acid
CHEMBL345
 EC50 6.52 6.52 300.0 2
Ribosomal RNA A-site
CHEMBL614640
 Kd 4.75 4.75 18000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked IC50 = 24.0 nM 7.62 Inhibitory activity against the displacement of Picogreen from fMet-tRNA(fMet) b... 12643896
Nucleic Acid Kd = 100.0 nM 7.0 Binding affinity to A-site RNA 19445516
Nucleic Acid EC50 = 300.0 nM 6.52 Binding affinity to Escherichia coli 16S rRNA helix 44 assessed as stabilization... 19946275
Nucleic Acid EC50 = 300.0 nM 6.52 Binding affinity to Escherichia coli 23S rRNA assessed as stabilization of class... 19946275
Unchecked IC50 = 17800.0 nM 4.75 Inhibitory activity of the aminoglycoside on Staphylococcus aureus IF-2 binding ... 12643896
Ribosomal RNA A-site Kd = 18000.0 nM 4.75 Binding affinity of aminoglycoside to 16S ribosomal RNA A-site in Escherichia co... 11206440

Literature References

PubMed DOI Target Context # Activities
19946275 10.1038/nchembio.274 Nucleic Acid 11
20145089 10.1128/aac.01444-09 Unchecked 9
20145089 10.1128/aac.01444-09 Escherichia coli 7
12643896 10.1016/s0960-894x(03)00085-4 Unchecked 5
22257890 10.1016/j.bmcl.2011.12.103 Nucleic Acid 5
107311 10.1021/jm00190a015 Pseudomonas aeruginosa 5
3543366 10.1021/jm00385a015 ADMET 4
107311 10.1021/jm00190a015 Escherichia coli 4
19012394 10.1021/jm800997s Unchecked 4
21177112 10.1016/j.bmc.2010.11.065 Staphylococcus epidermidis 3
18285485 10.1128/aac.01071-07 Pseudomonas aeruginosa 3
21177112 10.1016/j.bmc.2010.11.065 Escherichia coli 3
20373816 10.1021/jm1000437 Escherichia coli 3
- 10.1016/S0960-894X(97)00339-9 ADMET 3
17088479 10.1128/aac.01034-06 Escherichia coli 2
17088479 10.1128/aac.01034-06 Aminoglycoside 3'-phosphotransferase type IIb 2
19012394 10.1021/jm800997s Escherichia coli 2
20373816 10.1021/jm1000437 Staphylococcus aureus 2
21177112 10.1016/j.bmc.2010.11.065 Staphylococcus aureus 2
11327578 10.1016/s0960-894x(01)00115-9 Nucleic Acid 2

Data from ChEMBL 36 via Core Engine