Assay Detail
Binding
CHEMBL699213
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Inhibitory activity against the displacement of Picogreen from fMet-tRNA(fMet) by the aminoglycoside
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibition of bacterial IF2 binding to fMet-tRNA((fMet)) by aminoglycosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.96 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184618 | FRAMYCETIN | 3.0 | 1 | 8.05 |
| CHEMBL223520 | KANAMYCIN A | 1.0 | 1 | 7.62 |
| CHEMBL177 | AMIKACIN | 4.0 | 1 | 6.80 |
| CHEMBL1276484 | HYGROMYCIN | — | 1 | 6.56 |
| CHEMBL372795 | STREPTOMYCIN | 4.0 | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184618 | FRAMYCETIN | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL223520 | KANAMYCIN A | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL177 | AMIKACIN | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1276484 | HYGROMYCIN | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL372795 | STREPTOMYCIN | IC50 | = | 1790.0 | nM | 5.75 |