Compound Detail

CHEMBL184618

FRAMYCETIN

🧪 Phase III

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🧪 Phase III

NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL184618
Name	FRAMYCETIN
Phase	Phase III
Structure Type	MOL
InChI Key	PGBHMTALBVVCIT-VCIWKGPPSA-N

Known Names

Actilin Antibiotic 10676 ANTIBIOTIQUE EF 185 Dekamycin iii Enterfram Fradiomycin b Framicetina Framidal Framycetin Framycetine Framycin Framygen +2 more

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Indications

Molecular Properties

614.6

MW (Da)

-8.90

ALogP

HBA

HBD

353.1

PSA (Å²)

0.11

QED

Ro5 Violations

Rot. Bonds

Drug Information

Molecule Type	Small molecule
Chirality	Single Enantiomer

Flags

Natural Product

Extended Properties

Molecular Formula	C23H46N6O13
MW	614.65
Aromatic Rings	0
Heavy Atoms	42
NP-Likeness	1.11

Indications

Eye Infections Nasal Obstruction Osteomyelitis

ATC Classification

D09AA01

framycetin

Level 1: DERMATOLOGICALS

Level 2: MEDICATED DRESSINGS

R01AX08

framycetin

Level 1: RESPIRATORY SYSTEM

Level 2: NASAL PREPARATIONS

S01AA07

framycetin

Level 1: SENSORY ORGANS

Level 2: OPHTHALMOLOGICALS

Activity Summary

Kd 52 meas. best 9.0

IC50 28 meas. best 8.1

Ki 4 meas. best 8.15

EC50 1 meas. best 8.15

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Unchecked CHEMBL612545	Kd	9.0	6.0253	1.0	19
Nucleic Acid CHEMBL345	EC50	8.15	8.15	7.0	1
Lethal factor CHEMBL4372	Ki	8.15	7.225	7.0	2
Unchecked CHEMBL612545	IC50	8.1	5.5811	7.9	9
Ribosomal RNA A-site CHEMBL614640	Kd	7.72	7.72	19.0	1
Bacterial 70S ribosome CHEMBL2363135	IC50	7.5	7.5	32.0	1
Nucleic Acid CHEMBL345	Kd	7.22	6.1684	60.0	19
Ribosomal RNA A-site CHEMBL614640	IC50	7.12	7.0133	76.0	3
No relevant target CHEMBL2362975	Kd	7.0	6.1933	100.0	3
microRNA 21 CHEMBL1615322	Kd	7.0	6.105	100.0	4
Rev responsive element (RRE) RNA CHEMBL613297	Kd	6.75	6.59	180.0	2
Human immunodeficiency virus type 1 REV CHEMBL3852	Kd	6.75	6.75	180.0	1
Transient receptor potential cation channel subfamily V member 1 CHEMBL4794	IC50	6.4	6.4	400.0	1
Nucleic Acid CHEMBL345	IC50	6.38	6.0833	417.0	3
Bacillus subtilis CHEMBL359	Kd	5.07	5.07	8500.0	1
Escherichia coli CHEMBL354	IC50	4.98	4.98	10500.0	1
Unchecked CHEMBL612545	Ki	4.87	4.8	13500.0	2
Lecithin retinol acyltransferase CHEMBL2202	IC50	4.83	4.83	14900.0	1
Menin CHEMBL1615381	Kd	4.81	4.81	15600.0	1

Pharmacokinetic Data

Parameter	Value	Units	Species
Ka	2.6	10'7/M	-
Ka	9.9	10'6/M	-
Ka	1.6	10^-5M	Not specified

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Unchecked	Kd	=	1.0	nM	9.0	Binding affinity to 5'-fluorescein-tagged Escherichia coli ribosomal A site wt-b...	31610941
Unchecked	Kd	=	5.0	nM	8.3	Binding affinity to 5'-fluorescein-tagged bacterial ribosomal A site 27-nucleoti...	31610941
Lethal factor	Ki	=	7.0	nM	8.15	Binding affinity to Bacillus anthracis lethal factor assessed as inhibition cons...	34624823
Nucleic Acid	EC50	=	7.0	nM	8.15	Binding affinity to RNA by RNA fluorescence assay	21041083
Unchecked	IC50	=	7.9	nM	8.1	Inhibition of rat phospholipase C	20875743
Unchecked	IC50	=	9.0	nM	8.05	Inhibitory activity against the displacement of Picogreen from fMet-tRNA(fMet) b...	12643896
Ribosomal RNA A-site	Kd	=	19.0	nM	7.72	Binding affinity of aminoglycoside to 16S ribosomal RNA A-site in Escherichia co...	11206440
Bacterial 70S ribosome	IC50	=	32.0	nM	7.5	Binding affinity to Escherichia coli ribosome assessed as inhibition of transcri...	21041083
Unchecked	IC50	=	50.0	nM	7.3	Inhibitory activity of the aminoglycoside on Staphylococcus aureus IF-2 binding ...	12643896
Nucleic Acid	Kd	=	60.0	nM	7.22	Binding affinity to A-site RNA	19445516
Ribosomal RNA A-site	IC50	=	76.0	nM	7.12	Displacement of F-NEO from human cytosolic rRNA-A site after 10 to 20 mins by fl...	30530174
Ribosomal RNA A-site	IC50	=	87.0	nM	7.06	Displacement of F-NEO from Escherichia coli rRNA-A site after 10 to 20 mins by f...	30530174
Nucleic Acid	Kd	=	91.0	nM	7.04	Tested for binding affinity against RNA construct E	11814798
microRNA 21	Kd	=	100.0	nM	7.0	Binding affinity to biotinylated pre-miRNA-21 (unknown origin) by SPR analysis	31098005
No relevant target	Kd	=	100.0	nM	7.0	Dissociation constant of the compound	15293991
Unchecked	Kd	=	100.0	nM	7.0	Binding affinity to 5'-fluorescein-tagged human mitochondrial ribosome A site mu...	31610941
Nucleic Acid	Kd	=	120.0	nM	6.92	Dissociation constant for binding to mitochondrial 12S rRNA construct M3 was det...	12127547
Ribosomal RNA A-site	IC50	=	139.0	nM	6.86	Binding affinity to rRNA-A site in human MDA-MB-231 cells assessed as inhibition...	30530174
Nucleic Acid	Kd	=	140.0	nM	6.85	Dissociation constant for binding to mitochondrial 12S rRNA construct M2 was det...	12127547
Nucleic Acid	Kd	=	160.0	nM	6.8	Dissociation constant for binding to mitochondrial 12S rRNA construct M4 was det...	12127547

Literature References

PubMed	DOI	Target Context	# Activities
-	10.6019/CHEMBL3885881	Rattus norvegicus	569
18955526	10.1128/aac.00441-08	NON-PROTEIN TARGET	166
26264847	10.1016/j.bmc.2015.07.062	Unchecked	23
17060530	10.1128/aac.00261-06	Bifidobacterium longum	15
22194678	10.1371/journal.pcbi.1002310	Hepatotoxicity	14
19301822	10.1021/jm900028n	Escherichia coli	13
20000576	10.1021/jm900615h	Pseudomonas aeruginosa	12
17060530	10.1128/aac.00261-06	NON-PROTEIN TARGET	10
22257890	10.1016/j.bmcl.2011.12.103	Nucleic Acid	10
30530174	10.1016/j.ejmech.2018.11.022	Staphylococcus aureus	10
17060530	10.1128/aac.00261-06	Bifidobacterium bifidum	10
27076899	10.1039/c4md00165f	Nucleic Acid	10
31610941	10.1016/j.bmc.2019.115121	Unchecked	9
19946275	10.1038/nchembio.274	Nucleic Acid	9
24083676	10.1021/jm401148j	Staphylococcus aureus	8
17060530	10.1128/aac.00261-06	Bifidobacterium breve	8
20000576	10.1021/jm900615h	Staphylococcus aureus	8
10498188	10.1016/s0960-894x(99)00438-2	Rattus norvegicus	8
27076899	10.1039/c4md00165f	ADMET	8
18573660	10.1016/j.bmcl.2008.05.090	Unchecked	6

Data from ChEMBL 36 via Core Engine