Assay Detail
Binding
CHEMBL1638698
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Binding affinity to Escherichia coli ribosome assessed as inhibition of transcription-translational activity by luciferase assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Subcellular | Ribosome |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Second generation analogs of rigid 6,7-spiro scaffolds targeting the bacterial ribosome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.44 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184618 | FRAMYCETIN | 3.0 | 1 | 7.50 |
| CHEMBL427409 | NEAMINE | — | 1 | 5.30 |
| CHEMBL1631490 | — | — | 1 | 4.95 |
| CHEMBL1631496 | — | — | 1 | 4.01 |
| CHEMBL1631491 | — | — | 1 | - |
| CHEMBL1631492 | — | — | 1 | - |
| CHEMBL1631493 | — | — | 1 | - |
| CHEMBL1631494 | — | — | 1 | - |
| CHEMBL1631495 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184618 | FRAMYCETIN | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL427409 | NEAMINE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1631490 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL1631496 | — | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL1631491 | — | IC50 | = | 168000.0 | nM | - |
| CHEMBL1631492 | — | IC50 | = | 118000.0 | nM | - |
| CHEMBL1631493 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL1631494 | — | IC50 | = | 429000.0 | nM | - |
| CHEMBL1631495 | — | IC50 | = | 186000.0 | nM | - |