Bacterial 70S ribosome · PROTEIN NUCLEIC-ACID COMPLEX · Bacteria
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As of 2026-09-13Bacterial 70S ribosome shows approved-linked disease relevance led by osteomyelitis. 5 more disease programs remain visible in the same review block. 33 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P0A7V0. Start with osteomyelitis, then reuse UniProt P0A7V0 as the stable protein anchor across project notes and exports.
Start with osteomyelitis, then reuse UniProt P0A7V0 as the stable protein anchor across project notes and exports.
Bacterial 70S ribosome shows approved-linked disease relevance led by osteomyelitis. 5 more disease programs remain visible in the same review block. 33 linked drugs remain visible in the same block.
Start review with osteomyelitis because it currently carries approved-linked support. Linked drugs include AMIKACIN SULFATE, AZITHROMYCIN, BEKANAMYCIN, CHLORAMPHENICOL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxySmall ribosomal subunit protein uS2
Review this target as Bacterial 70S ribosome, mapped to UniProt P0A7V0. ChEMBL maps the protein component as Small ribosomal subunit protein uS2. Sequence length is 241 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Bacterial 70S ribosome as ChEMBL target CHEMBL2363135, mapped to UniProt P0A7V0. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Bacterial 70S ribosome is the right protein anchor across sources, using UniProt P0A7V0 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why osteomyelitis is currently framed as approved-linked support. It currently carries 33 linked drugs in the same disease frame.
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Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Bacterial 70S ribosome |
| Target Type | PROTEIN NUCLEIC-ACID COMPLEX |
| Organism | Bacteria |
| UniProt | P0A7V0 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Small ribosomal subunit protein uS2 |
| UniProt Accession | P0A7V0 |
| Component Type | Protein |
| Sequence Length | 241 aa |
Small ribosomal subunit protein uS2
Review this target as Bacterial 70S ribosome, mapped to UniProt P0A7V0. ChEMBL maps the protein component as Small ribosomal subunit protein uS2. Sequence length is 241 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Bacterial 70S ribosome shows approved-linked disease relevance led by osteomyelitis. 5 more disease programs remain visible in the same review block.
Start review with osteomyelitis because it currently carries approved-linked support. Linked drugs include AMIKACIN SULFATE, AZITHROMYCIN, BEKANAMYCIN, CHLORAMPHENICOL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1232510 | 9.22 | Kd | 0.6 | Clinical |
| CHEMBL4463502 | 8.85 | Kd | 1.4 | Preclinical |
| CHEMBL4203781 | 8.68 | Kd | 2.1 | Preclinical |
| CHEMBL4128170 | 8.62 | Kd | 2.4 | Preclinical |
| CHEMBL3335485 | 8.19 | Kd | 6.4 | Preclinical |
| CHEMBL1136 | 8.19 | Kd | 6.4 | Approved |
| CHEMBL1688546 | 8.12 | Kd | 7.5 | Preclinical |
| CHEMBL215226 | 8.05 | IC50 | 8.9 | Preclinical |
| CHEMBL532 | 7.96 | Kd | 11.0 | Approved |
| CHEMBL1572 | 7.7 | IC50 | 20.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| subcellular format | 35 | 66 | 6.5 |
| assay format | 28 | 72 | 5.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |