Compound Detail
CHEMBL1232510
SOLITHROMYCIN 🧪 Phase III
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🧪 Phase III
CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cc(-c4cccc(N)c4)nn3)C(=O)O[C@]12C
Basic Information
| ChEMBL ID | CHEMBL1232510 |
| Name | SOLITHROMYCIN |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | IXXFZUPTQVDPPK-ZAWHAJPISA-N |
1
Targets
2
Activities
2
Assay Types
2
PK Parameters
20
Publications
9
Known Names
5
Indications
Molecular Properties
845.0
MW (Da)
4.60
ALogP
15
HBA
2
HBD
197.9
PSA (Ų)
0.14
QED
2
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Indications
Bacterial Infections Gonorrhea Pneumonia, Bacterial Non-alcoholic Fatty Liver Disease Pulmonary Disease, Chronic Obstructive
ATC Classification
J01FA16
solithromycin
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIBACTERIALS FOR SYSTEMIC USE
Activity Summary
Kd 1 meas. best 9.22
Ki 1 meas. best 7.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bacterial 70S ribosome CHEMBL2363135 | Kd | 9.22 | 9.22 | 0.6 | 1 |
| Bacterial 70S ribosome CHEMBL2363135 | Ki | 7.22 | 7.22 | 60.3 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 5.0 | hr | Homo sapiens |
| Tmax | 4.0 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Bacterial 70S ribosome | Kd | = | 0.6 | nM | 9.22 | Binding affinity to Escherichia coli 70S ribosome assessed as reduction in BODIP... | 31820982 |
| Bacterial 70S ribosome | Ki | = | 60.3 | nM | 7.22 | Binding affinity to Staphylococcus aureus 70S ribosome assessed as reduction in ... | 33477021 |
Literature References
Data from ChEMBL 36 via Core Engine