Assay Detail
Binding
CHEMBL4357306
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Binding affinity to Escherichia coli 70S ribosome assessed as reduction in BODIPY-Erythromycin A binding incubated for 1 hr by fluorescence polarization assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Subcellular | Ribosome |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Kinetic Target-Guided Synthesis: Reaching the Age of Maturity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 8.92 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1232510 | SOLITHROMYCIN | 3.0 | 1 | 9.22 |
| CHEMBL4463502 | — | — | 1 | 8.85 |
| CHEMBL4203781 | — | — | 1 | 8.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1232510 | SOLITHROMYCIN | Kd | = | 0.6 | nM | 9.22 |
| CHEMBL4463502 | — | Kd | = | 1.4 | nM | 8.85 |
| CHEMBL4203781 | — | Kd | = | 2.1 | nM | 8.68 |