Compound Detail
CHEMBL1688546
KOSAN-1325 Enter ChEMBL ID:
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C[C@H]1C(=O)O[C@H](CCNC(=O)Cc2cccc(-c3ccco3)c2)[C@@]2(C)OC(=O)N[C@@H]2[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)C2O)[C@@H](C)C1=O
Basic Information
| ChEMBL ID | CHEMBL1688546 |
| Name | KOSAN-1325 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DMSLVPBURQTCAM-DSPQCSRZSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
797.9
MW (Da)
3.42
ALogP
13
HBA
4
HBD
203.2
PSA (Ų)
0.21
QED
2
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 8.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bacterial 70S ribosome CHEMBL2363135 | Kd | 8.12 | 8.12 | 7.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Bacterial 70S ribosome | Kd | = | 7.5 | nM | 8.12 | Displacement of [14C]-erythromycin from Escherichia coli K-12 70S ribosome after... | 19164155 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19164155 | 10.1128/aac.01425-08 | Bacterial 70S ribosome | 6 |
| 19164155 | 10.1128/aac.01425-08 | Unchecked | 6 |
| 19164155 | 10.1128/aac.01425-08 | Nucleic Acid | 5 |
| 19164155 | 10.1128/aac.01425-08 | Escherichia coli | 3 |
Data from ChEMBL 36 via Core Engine