Assay Detail
ADMET
CHEMBL4368760
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to 5'-fluorescein-tagged human mitochondrial ribosome A site mutant duplex RNA incubated for 2 mins by fluorescence spectrophotometry analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Use of a fluorescence assay to determine relative affinities of semisynthetic aminoglycosides to small RNAs representing bacterial and mitochondrial A sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 5.72 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184618 | FRAMYCETIN | 3.0 | 1 | 7.00 |
| CHEMBL370143 | PAROMOMYCIN | 4.0 | 1 | 5.55 |
| CHEMBL4538701 | — | — | 1 | 5.24 |
| CHEMBL4448326 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184618 | FRAMYCETIN | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL370143 | PAROMOMYCIN | Kd | = | 2800.0 | nM | 5.55 |
| CHEMBL4538701 | — | Kd | = | 5800.0 | nM | 5.24 |
| CHEMBL4448326 | — | Kd | = | 8600.0 | nM | 5.07 |