Assay Detail
Binding
CHEMBL768316
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for binding affinity against RNA construct E
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Intermediate |
Publication
Binding of aminoglycoside antibiotics with modified A-site 16S rRNA construct containing non-nucleotide linkers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 6.55 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2368770 | — | — | 1 | 7.09 |
| CHEMBL184618 | FRAMYCETIN | 3.0 | 1 | 7.04 |
| CHEMBL370143 | PAROMOMYCIN | 4.0 | 1 | 6.40 |
| CHEMBL1747 | TOBRAMYCIN | 4.0 | 1 | 6.17 |
| CHEMBL176 | BEKANAMYCIN | 3.0 | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2368770 | — | Kd | = | 81.0 | nM | 7.09 |
| CHEMBL184618 | FRAMYCETIN | Kd | = | 91.0 | nM | 7.04 |
| CHEMBL370143 | PAROMOMYCIN | Kd | = | 400.0 | nM | 6.40 |
| CHEMBL1747 | TOBRAMYCIN | Kd | = | 680.0 | nM | 6.17 |
| CHEMBL176 | BEKANAMYCIN | Kd | = | 910.0 | nM | 6.04 |