Compound Detail
CHEMBL2368770
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CN(C)C1=CC2Oc3cc(N(C)C)ccc3C(c3ccc(C(=O)NC[C@@H]4O[C@H](O[C@H]5[C@@H](O)[C@H](O[C@@H]6[C@H](O)[C@H](N)C[C@@H](N)[C@H]6O[C@H]6O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]6N)O[C@@H]5CO)[C@H](N)[C@H](O)[C@@H]4O)cc3C(=O)O)=C2C=C1
Basic Information
| ChEMBL ID | CHEMBL2368770 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FTQIPUIASISKOY-KFALYHEVSA-N |
3
Targets
7
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
1030.1
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 7 meas. best 7.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nucleic Acid CHEMBL345 | Kd | 7.09 | 6.392 | 81.0 | 5 |
| Unchecked CHEMBL612545 | Kd | 6.55 | 6.55 | 280.0 | 1 |
| Human immunodeficiency virus type 1 REV CHEMBL3852 | Kd | 6.3 | 6.3 | 500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nucleic Acid | Kd | = | 81.0 | nM | 7.09 | Tested for binding affinity against RNA construct E | 11814798 |
| Unchecked | Kd | = | 280.0 | nM | 6.55 | Dissociation constant with dimeric 16S rRNA RNA construct B | 11677142 |
| Nucleic Acid | Kd | = | 310.0 | nM | 6.51 | Tested for binding affinity against RNA construct B | 11814798 |
| Nucleic Acid | Kd | = | 330.0 | nM | 6.48 | Tested for binding affinity against RNA construct A | 11814798 |
| Nucleic Acid | Kd | = | 340.0 | nM | 6.47 | Tested for binding affinity against RNA construct D | 11814798 |
| Human immunodeficiency virus type 1 REV | Kd | = | 500.0 | nM | 6.3 | Tested for the ability to bind the HIV-1 RRE-RNA construct by fluorescence aniso... | 11354359 |
| Nucleic Acid | Kd | = | 3890.0 | nM | 5.41 | Tested for binding affinity against RNA construct C | 11814798 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11814798 | 10.1016/s0960-894x(01)00760-0 | Nucleic Acid | 5 |
| 11354359 | 10.1016/s0960-894x(01)00149-4 | Human immunodeficiency virus type 1 REV | 1 |
| 11677142 | 10.1016/s0960-894x(01)00602-3 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine