Assay Detail
Functional
CHEMBL691409
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Tested for the ability to bind the HIV-1 RRE-RNA construct by fluorescence anisotropy
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 REV (CHEMBL3852) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Binding of dimeric aminoglycosides to the HIV-1 rev responsive element (RRE) RNA construct.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 6.45 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384228 | — | — | 1 | 8.00 |
| CHEMBL3037952 | — | — | 1 | 6.80 |
| CHEMBL184618 | FRAMYCETIN | 3.0 | 1 | 6.75 |
| CHEMBL2368770 | — | — | 1 | 6.30 |
| CHEMBL2367766 | Tobramycin-Tobramycin | — | 1 | 5.43 |
| CHEMBL1747 | TOBRAMYCIN | 4.0 | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384228 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL3037952 | — | Kd | = | 160.0 | nM | 6.80 |
| CHEMBL184618 | FRAMYCETIN | Kd | = | 180.0 | nM | 6.75 |
| CHEMBL2368770 | — | Kd | = | 500.0 | nM | 6.30 |
| CHEMBL2367766 | Tobramycin-Tobramycin | Kd | = | 3690.0 | nM | 5.43 |
| CHEMBL1747 | TOBRAMYCIN | Kd | = | 4110.0 | nM | 5.39 |