Human immunodeficiency virus type 1 REV · SINGLE PROTEIN · Human immunodeficiency virus 1
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As of 2026-09-14Protein identity stays anchored to UniProt Q77Y21. Use UniProt Q77Y21 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q77Y21 as the stable identity anchor, then attach disease evidence before program review.
Protein Rev
Review this target as Human immunodeficiency virus type 1 REV, mapped to UniProt Q77Y21. ChEMBL maps the protein component as Protein Rev. Sequence length is 116 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Human immunodeficiency virus type 1 REV as ChEMBL target CHEMBL3852, mapped to UniProt Q77Y21. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Human immunodeficiency virus type 1 REV is the right protein anchor across sources, using UniProt Q77Y21 as the stable mapping.
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| Preferred Name | Human immunodeficiency virus type 1 REV |
| Target Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
| UniProt | Q77Y21 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Protein Rev |
| UniProt Accession | Q77Y21 |
| Component Type | Protein |
| Sequence Length | 116 aa |
Protein Rev
Review this target as Human immunodeficiency virus type 1 REV, mapped to UniProt Q77Y21. ChEMBL maps the protein component as Protein Rev. Sequence length is 116 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL415806 | 8.47 | Kd | 3.38 | Preclinical |
| CHEMBL349996 | 8.07 | Kd | 8.5 | Preclinical |
| CHEMBL384228 | 8.0 | Kd | 10.0 | Preclinical |
| CHEMBL3037952 | 6.8 | Kd | 160.0 | Preclinical |
| CHEMBL184618 | 6.75 | Kd | 180.0 | Clinical |
| CHEMBL152397 | 6.62 | Kd | 240.0 | Preclinical |
| CHEMBL349996 | 6.46 | IC50 | 350.0 | Preclinical |
| CHEMBL155256 | 6.34 | IC50 | 460.0 | Preclinical |
| CHEMBL2368770 | 6.3 | Kd | 500.0 | Preclinical |
| CHEMBL2367766 | 5.43 | Kd | 3690.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 4 | 5 | 6.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 6 | 6.5 |