Compound Detail
CHEMBL155256
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Basic Information
| ChEMBL ID | CHEMBL155256 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JPBLSVNUKDDJAB-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
478.6
MW (Da)
-6.58
ALogP
12
HBA
11
HBD
297.0
PSA (Ų)
0.08
QED
2
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 REV CHEMBL3852 | IC50 | 6.34 | 6.34 | 460.0 | 1 |
| Protein Tat CHEMBL4609 | IC50 | 6.22 | 6.22 | 600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 REV | IC50 | = | 460.0 | nM | 6.34 | Inhibitory activity against peptide binding to the RRE RNA was determined | 11229778 |
| Protein Tat | IC50 | = | 600.0 | nM | 6.22 | Inhibition of Tat peptide binding to HIV-1 TAR RNA | 11229778 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11229778 | 10.1016/s0960-894x(01)00005-1 | Protein Tat | 1 |
| 11229778 | 10.1016/s0960-894x(01)00005-1 | Human immunodeficiency virus type 1 REV | 1 |
Data from ChEMBL 36 via Core Engine