Assay Detail
Binding
CHEMBL771472
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Inhibitory activity against peptide binding to the RRE RNA was determined
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 REV (CHEMBL3852) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.51 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL155256 | — | — | 1 | 6.34 |
| CHEMBL427409 | NEAMINE | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL155256 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL427409 | NEAMINE | IC50 | = | 21000.0 | nM | 4.68 |