Compound Detail
CHEMBL2367766
Tobramycin-Tobramycin Enter ChEMBL ID:
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NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CSCCOCCSSCCOCCSC[C@H]4O[C@H](O[C@@H]5[C@@H](O)[C@H](O[C@H]6O[C@H](CN)[C@@H](O)C[C@H]6N)[C@@H](N)C[C@H]5N)[C@H](O)[C@@H](N)[C@@H]4O)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)C[C@@H]1O
Basic Information
| ChEMBL ID | CHEMBL2367766 |
| Name | Tobramycin-Tobramycin |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DRKCFEIKVASKQV-HWJHIZAWSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
1173.5
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 4 meas. best 5.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nucleic Acid CHEMBL345 | Kd | 5.75 | 5.745 | 1780.0 | 2 |
| Unchecked CHEMBL612545 | Kd | 5.74 | 5.74 | 1810.0 | 1 |
| Human immunodeficiency virus type 1 REV CHEMBL3852 | Kd | 5.43 | 5.43 | 3690.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nucleic Acid | Kd | = | 1780.0 | nM | 5.75 | Dissociation constant towards 16S rRNA construct A | 10915059 |
| Nucleic Acid | Kd | = | 1810.0 | nM | 5.74 | Dissociation constant towards 16S rRNA construct B | 10915059 |
| Unchecked | Kd | = | 1810.0 | nM | 5.74 | Dissociation constant with dimeric 16S rRNA RNA construct B | 11677142 |
| Human immunodeficiency virus type 1 REV | Kd | = | 3690.0 | nM | 5.43 | Tested for the ability to bind the HIV-1 RRE-RNA construct by fluorescence aniso... | 11354359 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(97)00339-9 | ADMET | 3 |
| 10915059 | 10.1016/s0960-894x(00)00299-7 | Nucleic Acid | 2 |
| 11354359 | 10.1016/s0960-894x(01)00149-4 | Human immunodeficiency virus type 1 REV | 1 |
| 11677142 | 10.1016/s0960-894x(01)00602-3 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine