Assay Detail
Binding
CHEMBL615152
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Dissociation constant towards 16S rRNA construct B
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Intermediate |
Publication
Enhanced binding of aminoglycoside dimers to a "dimerized" A-site 16S rRNA construct.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 6.45 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3038046 | — | — | 1 | 7.70 |
| CHEMBL3037952 | — | — | 1 | 6.54 |
| CHEMBL2368771 | — | — | 1 | 6.54 |
| CHEMBL184618 | FRAMYCETIN | 3.0 | 1 | 6.42 |
| CHEMBL1747 | TOBRAMYCIN | 4.0 | 1 | 5.78 |
| CHEMBL2367766 | Tobramycin-Tobramycin | — | 1 | 5.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3038046 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL3037952 | — | Kd | = | 290.0 | nM | 6.54 |
| CHEMBL2368771 | — | Kd | = | 290.0 | nM | 6.54 |
| CHEMBL184618 | FRAMYCETIN | Kd | = | 380.0 | nM | 6.42 |
| CHEMBL1747 | TOBRAMYCIN | Kd | = | 1680.0 | nM | 5.78 |
| CHEMBL2367766 | Tobramycin-Tobramycin | Kd | = | 1810.0 | nM | 5.74 |