Assay Detail
Binding
CHEMBL767650
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Tested for binding affinity against RNA construct B
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Intermediate |
Publication
Binding of aminoglycoside antibiotics with modified A-site 16S rRNA construct containing non-nucleotide linkers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 5.99 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2368770 | — | — | 1 | 6.51 |
| CHEMBL184618 | FRAMYCETIN | 3.0 | 1 | 6.42 |
| CHEMBL370143 | PAROMOMYCIN | 4.0 | 1 | 5.80 |
| CHEMBL1747 | TOBRAMYCIN | 4.0 | 1 | 5.69 |
| CHEMBL176 | BEKANAMYCIN | 3.0 | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2368770 | — | Kd | = | 310.0 | nM | 6.51 |
| CHEMBL184618 | FRAMYCETIN | Kd | = | 380.0 | nM | 6.42 |
| CHEMBL370143 | PAROMOMYCIN | Kd | = | 1580.0 | nM | 5.80 |
| CHEMBL1747 | TOBRAMYCIN | Kd | = | 2040.0 | nM | 5.69 |
| CHEMBL176 | BEKANAMYCIN | Kd | = | 2900.0 | nM | 5.54 |