Assay Detail
Binding
CHEMBL699214
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Inhibitory activity of the aminoglycoside on Staphylococcus aureus IF-2 binding to fMet-tRNA(fMet)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibition of bacterial IF2 binding to fMet-tRNA((fMet)) by aminoglycosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.73 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184618 | FRAMYCETIN | 3.0 | 1 | 7.30 |
| CHEMBL301721 | GENTAMICIN C1A | — | 1 | 6.35 |
| CHEMBL177 | AMIKACIN | 4.0 | 1 | 5.99 |
| CHEMBL372795 | STREPTOMYCIN | 4.0 | 1 | 5.83 |
| CHEMBL223520 | KANAMYCIN A | 1.0 | 1 | 4.75 |
| CHEMBL1276484 | HYGROMYCIN | — | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184618 | FRAMYCETIN | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL301721 | GENTAMICIN C1A | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL177 | AMIKACIN | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL372795 | STREPTOMYCIN | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL223520 | KANAMYCIN A | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL1276484 | HYGROMYCIN | IC50 | = | 66000.0 | nM | 4.18 |