Assay Detail
Binding
CHEMBL4331684
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Displacement of F-NEO from Escherichia coli rRNA-A site after 10 to 20 mins by fluorescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis, antimicrobial activity, attenuation of aminoglycoside resistance in MRSA, and ribosomal A-site binding of pyrene-neomycin conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.75 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184618 | FRAMYCETIN | 3.0 | 1 | 7.06 |
| CHEMBL4442608 | — | — | 1 | 7.02 |
| CHEMBL4536151 | — | — | 1 | 6.83 |
| CHEMBL445770 | — | — | 1 | 6.77 |
| CHEMBL4457923 | — | — | 1 | 6.72 |
| CHEMBL4459175 | — | — | 1 | 6.59 |
| CHEMBL4438817 | — | — | 1 | 6.52 |
| CHEMBL4527321 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184618 | FRAMYCETIN | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL4442608 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4536151 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL445770 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4457923 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL4459175 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL4438817 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL4527321 | — | IC50 | = | 310.0 | nM | 6.51 |