Assay Detail
Binding
CHEMBL4331732
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Binding affinity to rRNA-A site in human MDA-MB-231 cells assessed as inhibition of protein translation
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis, antimicrobial activity, attenuation of aminoglycoside resistance in MRSA, and ribosomal A-site binding of pyrene-neomycin conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.13 | 6.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184618 | FRAMYCETIN | 3.0 | 1 | 6.86 |
| CHEMBL4459175 | — | — | 1 | 6.67 |
| CHEMBL4442608 | — | — | 1 | 6.57 |
| CHEMBL4536151 | — | — | 1 | 6.03 |
| CHEMBL4438817 | — | — | 1 | 5.92 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184618 | FRAMYCETIN | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL4459175 | — | IC50 | = | 212.6 | nM | 6.67 |
| CHEMBL4442608 | — | IC50 | = | 268.8 | nM | 6.57 |
| CHEMBL4536151 | — | IC50 | = | 927.0 | nM | 6.03 |
| CHEMBL4438817 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 18080.0 | nM | 4.74 |