Assay Detail
Binding
CHEMBL1638697
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Binding affinity to RNA by RNA fluorescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Second generation analogs of rigid 6,7-spiro scaffolds targeting the bacterial ribosome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.23 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184618 | FRAMYCETIN | 3.0 | 1 | 8.15 |
| CHEMBL1631490 | — | — | 1 | 5.19 |
| CHEMBL1631495 | — | — | 1 | 5.16 |
| CHEMBL1631493 | — | — | 1 | 5.08 |
| CHEMBL427409 | NEAMINE | — | 1 | 5.02 |
| CHEMBL1631496 | — | — | 1 | 4.92 |
| CHEMBL1631494 | — | — | 1 | 4.20 |
| CHEMBL1631492 | — | — | 1 | 4.13 |
| CHEMBL1631491 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184618 | FRAMYCETIN | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1631490 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1631495 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL1631493 | — | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL427409 | NEAMINE | EC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL1631496 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1631494 | — | EC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL1631492 | — | EC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL1631491 | — | EC50 | = | 141000.0 | nM | - |