Compound Detail
CHEMBL384124
GENTAMICIN C Enter ChEMBL ID:
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CN[C@@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@H](CN)CC[C@H]3N)[C@@H](N)C[C@H]2N)OC[C@]1(C)O
Basic Information
| ChEMBL ID | CHEMBL384124 |
| Name | GENTAMICIN C |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VEGXETMJINRLTH-HKHRZCBZSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
449.6
MW (Da)
-3.98
ALogP
12
HBA
8
HBD
213.7
PSA (Ų)
0.19
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 5.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ribosomal RNA A-site CHEMBL614640 | Kd | 5.26 | 5.26 | 5530.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ribosomal RNA A-site | Kd | = | 5530.0 | nM | 5.26 | Binding affinity to bacterial ribosomal A site RNA oligonucleotide | 16942021 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16942021 | 10.1021/jm060288o | Ribosomal RNA A-site | 1 |
Data from ChEMBL 36 via Core Engine