Assay Detail
Binding
CHEMBL880875
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Dissociation constant against 16S rRNA A-site
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Expert |
Publication
The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 5.24 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370143 | PAROMOMYCIN | 4.0 | 1 | 7.00 |
| CHEMBL412096 | — | — | 1 | 5.82 |
| CHEMBL371500 | — | — | 1 | 5.70 |
| CHEMBL427409 | NEAMINE | — | 1 | 5.30 |
| CHEMBL371080 | — | — | 1 | 5.00 |
| CHEMBL445402 | — | — | 1 | 4.57 |
| CHEMBL197808 | — | — | 1 | 4.46 |
| CHEMBL371237 | — | — | 1 | 4.06 |
| CHEMBL436502 | — | — | 1 | - |
| CHEMBL198549 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370143 | PAROMOMYCIN | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL412096 | — | Kd | = | 1500.0 | nM | 5.82 |
| CHEMBL371500 | — | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL427409 | NEAMINE | Kd | = | 5000.0 | nM | 5.30 |
| CHEMBL371080 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL445402 | — | Kd | = | 27000.0 | nM | 4.57 |
| CHEMBL197808 | — | Kd | = | 35000.0 | nM | 4.46 |
| CHEMBL371237 | — | Kd | = | 88000.0 | nM | 4.06 |
| CHEMBL436502 | — | Kd | = | 241000.0 | nM | - |
| CHEMBL198549 | — | Kd | = | 315000.0 | nM | - |